{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:26:13Z","timestamp":1791977173742,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T00:00:00Z","timestamp":1456358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Dialysis"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypermagnesemia is an uncommon electrolyte abnormality, due to the fact that magnesium toxicity is only seen in the setting of a massive exposure to exogenous magnesium, often in the setting of renal insufficiency. Here, we report a case of severe hypermagnesemia that resulted in complete paralysis that was secondary to Renacidin administration, a rarely used agent used for intra\u2010renal pelvic or intra\u2010vesicular instillation dissolution of struvite stones. The patient also had concurrent acute kidney injury (<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>). The patient's magnesium was as high as 16.7 mg\/dL, and he initially received hemodialysis followed by continuous venovenous hemodialysis. These therapies resulted in a rapid reduction in magnesium levels and eventual resolution of the muscular weakness. The case discussion highlights several key aspects of magnesium homeostasis, the limited mechanistic understanding of Renacidin\u2010induced hypermagnesemia, and the role of renal replacement therapies in the treatment of hypermagnesemia.<\/jats:p>","DOI":"10.1111\/sdi.12479","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T08:58:23Z","timestamp":1456477103000},"page":"247-250","source":"Crossref","is-referenced-by-count":4,"title":["An Unusual yet \u201cMg\u201dnificent Indication for Hemodialysis"],"prefix":"10.1111","volume":"29","author":[{"given":"Amar D.","family":"Bansal","sequence":"first","affiliation":[{"name":"Renal Electrolyte and Hypertension Division Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Negoianu","sequence":"additional","affiliation":[{"name":"Renal Electrolyte and Hypertension Division Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M.","family":"Warburton","sequence":"additional","affiliation":[{"name":"Renal Electrolyte and Hypertension Division Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,25]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"313","article-title":"The current role of percutaneous chemolysis in the management of urolithiasis: review and results","volume":"111","author":"Kachrilas S","year":"2013","journal-title":"J Urol"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-0143(05)70264-0"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(93)90566-S"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)51676-6"},{"key":"e_1_2_4_6_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000473388","article-title":"Hemiacidrin: a useful component in the treatment of infectious renal stones","volume":"15","author":"Wall I","year":"1987","journal-title":"Eur Urol"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1983.tb03300.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2007.9916"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2007.05.006"},{"key":"e_1_2_4_10_1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0022-5347(17)49851-X","article-title":"Hypermagnesemia associated with hemiacidrin irrigation","volume":"132","author":"Thompson IM","year":"1984","journal-title":"J Urol"},{"key":"e_1_2_4_11_1","first-page":"266","article-title":"Hypermagnesemia and progression of renal failure associated with renacidin therapy","volume":"25","author":"Wilson C","year":"1986","journal-title":"Clin Nephrol"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1978.03290130072028"},{"key":"e_1_2_4_13_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0022-5347(17)59955-3","article-title":"Hypermagnesemia in a uremic patient during renal pelvis irrigation with renacidin","volume":"111","author":"Cato AR","year":"1974","journal-title":"J Urol"},{"key":"e_1_2_4_14_1","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1001\/archinte.1985.00360090068012","article-title":"Magnesium toxicity as a cause of hypotension and hypoventilation. 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