{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T03:53:11Z","timestamp":1754020391177},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,7]],"date-time":"2016-05-07T00:00:00Z","timestamp":1462579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Dialysis"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In women, children, and smaller adults, dialysis adequacy targets based solely on <jats:italic>Kt<\/jats:italic>\/<jats:italic>V<\/jats:italic> might result not only in shorter treatments with inadequate fluid removal and undesirably rapid ultrafiltration rates, but also in less than optimal removal of small and middle molecular weight solutes if fractional removal is considered in relation to body surface area. The outcomes evidence for this is not definitive, but is suggested by a prespecified secondary analysis of the randomized <jats:styled-content style=\"fixed-case\">HEMO<\/jats:styled-content> trial results, and is supported by observational data. Also, there is evidence from normal renal physiology that in healthy humans of different body size, glomerular filtration rate (<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>) scales more closely to body surface area than to total body water. With these factors in mind, time on <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> may need to be greater than that predicted by standard <jats:italic>KT<\/jats:italic>\/<jats:italic>V<\/jats:italic> measurements to maximize survival in women and in smaller patients.<\/jats:p>","DOI":"10.1111\/sdi.12510","type":"journal-article","created":{"date-parts":[[2016,5,7]],"date-time":"2016-05-07T15:09:30Z","timestamp":1462633770000},"page":"303-305","source":"Crossref","is-referenced-by-count":4,"title":["We Underdialyze Women and Smaller Patients"],"prefix":"10.1111","volume":"29","author":[{"given":"John T.","family":"Daugirdas","sequence":"first","affiliation":[{"name":"Department of Medicine University of Illinois at Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.204"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021583"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02350310"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00519.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06340710"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00390112"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05581008"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01640309"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08171109"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12439"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.08.007"},{"key":"e_1_2_10_13_1","first-page":"20A","article-title":"Body size and gender dependent differences in mortality risks associated with ultrafiltration rates","volume":"25","author":"Larkin JW","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp071"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.457"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.01.008"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.07.015"}],"container-title":["Seminars in Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsdi.12510","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sdi.12510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T04:07:27Z","timestamp":1695701247000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sdi.12510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,7]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/sdi.12510"],"URL":"https:\/\/doi.org\/10.1111\/sdi.12510","archive":["Portico"],"relation":{},"ISSN":["0894-0959","1525-139X"],"issn-type":[{"value":"0894-0959","type":"print"},{"value":"1525-139X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,7]]}}}