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Risk factors for IDH include patient demographics, anti\u2010hypertensive medication use, larger interdialytic weight gain, and dialysis prescription features as dialysate sodium, high ultrafiltration rate, and dialysate temperature. A high frequency of IDH events carries a substantial death risk. An ultrafiltration rate &gt;10 mL\/h\/kg, and even more so &gt;13 mL\/h\/kg, is highly predictive of cardiovascular and all\u2010cause mortality. Evidence suggests that IDH causes acute reversible segmental myocardial hypoperfusion and contractile dysfunction (myocardial stunning), which can result in long\u2010term loss of myocardial contractility, leading to premature death. IDH also has negative end\u2010organ effects on the brain and gut, contributing to mortality through stroke, and endotoxin translocation with associated inflammation and protein\u2010energy wasting. Given strong association of IDH and dialysis mortality, a paradigm shift to its approach is urgently needed. Randomized controlled trials are required to prospectively test drugs and monitoring devices which may reduce IDH.<\/jats:p>","DOI":"10.1111\/sdi.12627","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T15:32:56Z","timestamp":1498750376000},"page":"473-480","source":"Crossref","is-referenced-by-count":110,"title":["A brief review of intradialytic hypotension with a focus on survival"],"prefix":"10.1111","volume":"30","author":[{"given":"Jason A.","family":"Chou","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension Harold Simmons Center for Kidney Disease Research and Epidemiology Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamyar","family":"Kalantar\u2010Zadeh","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Harold Simmons Center for Kidney Disease Research and Epidemiology Los Angeles CA USA"},{"name":"Fielding School of Public Health at 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