{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:18:39Z","timestamp":1790389119238,"version":"4.1.0"},"reference-count":107,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,26]],"date-time":"2017-11-26T00:00:00Z","timestamp":1511654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001232","name":"Royal Australasian College of Physicians","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Dialysis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In patients receiving hemodialysis, the provision of safe and effective vascular access using an arteriovenous fistula or graft is regarded as a critical priority by patients and health professionals. Vascular access failure is associated with morbidity and mortality, such that strategies to prevent these outcomes are essential. Inadequate vascular remodeling and neointimal hyperplasia resulting in stenosis and frequently thrombosis are critical to the pathogenesis of access failure. Systemic medical therapies with pleiotropic effects including antiplatelet agents, omega\u20103 polyunsaturated fatty acids (fish oils), statins, and inhibitors of the renin\u2010angiotensin\u2010aldosterone system (\n                    <jats:styled-content style=\"fixed-case\">RAAS<\/jats:styled-content>\n                    ) may reduce vascular access failure by promoting vascular access maturation and reducing stenosis and thrombosis through antiproliferative, antiaggregatory, anti\u2010inflammatory and vasodilatory effects. Despite such promise, the results of retrospective analyses and randomized controlled trials of these agents on arteriovenous fistula and graft outcomes have been mixed. This review describes the current understanding of the pathogenesis of arteriovenous fistula and graft failure, the biological effects of antiplatelet agents, fish oil supplementation,\n                    <jats:styled-content style=\"fixed-case\">RAAS<\/jats:styled-content>\n                    blockers and statins that may be beneficial in improving vascular access survival, results from clinical trials that have investigated the effect of these agents on arteriovenous fistula and graft outcomes, and it explores future therapeutic approaches combining these agents with novel treatment strategies.\n                  <\/jats:p>","DOI":"10.1111\/sdi.12658","type":"journal-article","created":{"date-parts":[[2017,11,26]],"date-time":"2017-11-26T21:02:47Z","timestamp":1511730167000},"page":"244-257","source":"Crossref","is-referenced-by-count":83,"title":["The pathogenesis of hemodialysis vascular access failure and systemic therapies for its prevention: Optimism unfulfilled"],"prefix":"10.1111","volume":"31","author":[{"given":"Andrea K","family":"Viecelli","sequence":"first","affiliation":[{"name":"Department of Nephrology Princess Alexandra Hospital Brisbane Qld Australia"},{"name":"Australasian Kidney Trials Network School of Medicine University of Queensland Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor A","family":"Mori","sequence":"additional","affiliation":[{"name":"Medical School University of Western Australia Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabir","family":"Roy\u2010Chaudhury","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Arizona College of Medicine and Southern Arizona VA Healthcare System Tucson AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevan R","family":"Polkinghorne","sequence":"additional","affiliation":[{"name":"Department of Nephrology Monash Medical Centre Melbourne Vic. Australia"},{"name":"School of Public Health and Preventive Medicine Monash University Melbourne Vic. Australia"},{"name":"Department of Medicine Monash University Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmel M","family":"Hawley","sequence":"additional","affiliation":[{"name":"Department of Nephrology Princess Alexandra Hospital Brisbane Qld Australia"},{"name":"Australasian Kidney Trials Network School of Medicine University of Queensland Brisbane Qld Australia"},{"name":"Translational Research Institute Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Nephrology Princess Alexandra Hospital Brisbane Qld Australia"},{"name":"Australasian Kidney Trials Network School of Medicine University of Queensland Brisbane Qld Australia"},{"name":"Translational Research Institute Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine M","family":"Pascoe","sequence":"additional","affiliation":[{"name":"Australasian Kidney Trials Network School of Medicine 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