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Sympathetic hyperactivity, predominantly due to afferent nerve signaling from the diseased native kidneys, has been established to be prognostic in the dialysis population for over 15\u00a0years. Despite this, tangible therapeutic interventions have, to date, been unsuccessful and the outlook for patients remains poor. This narrative review summarizes established experimental and clinical data, highlighting recent developments, and proposes why interventions to ameliorate sympathetic hyperactivity may well be beneficial for this high\u2010risk population.<\/jats:p>","DOI":"10.1111\/sdi.12756","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T08:43:25Z","timestamp":1542789805000},"page":"255-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sympathetic overactivity in dialysis patients\u2014Underappreciated and clinically consequential"],"prefix":"10.1111","volume":"32","author":[{"given":"Neil A.","family":"Hoye","sequence":"first","affiliation":[{"name":"Department of Renal Medicine South Tees Hospitals NHS Foundation Trust Middlesbrough UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke C.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department 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