{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:39:07Z","timestamp":1790786347080,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Dialysis"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    During the last two decades, oxidative stress (OS) has emerged as a novel risk factor for a variety of adverse events, including atherosclerosis and mortality in chronic kidney disease (CKD) patients. Increased OS occurs even in early stages of the disease, progresses with deterioration of renal function and is further aggravated by hemodialysis (HD), due to the bioincompatibility of the method. Compared to HD, peritoneal dialysis (PD) is a more biocompatible dialysis modality, characterized by a significantly reduced, but still high, OS status. The culprit for OS in PD is mainly the composition of PD solutions (low pH, lactate buffer, increased osmolarity and high glucose concentration). After heat sterilization of PD solutions, formation of glucose degradation products (GDPs) and advanced glycation end\u2010products (AGEs) trigger inflammation and enhance OS. Chronic exposure of the peritoneum to this toxic, hyperglycemic environment leads to OS\u2010derived morphologic damage of peritoneal cells, loss of ultrafiltration capacity and decreased technique survival. Moreover, OS is linked with peritonitis, loss of residual renal function, inflammation, atherosclerosis, cardiovascular (CV) disease, and increased mortality. To ameliorate OS status in PD, a multitargeted approach is necessary that includes use of neutral pH, low GDP, low lactate and iso\u2010ismolar PD solutions, strict glycemic control, optimal volume management and, probably supplementation with antioxidants,\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylcysteine being the most promising among them.\n                  <\/jats:p>","DOI":"10.1111\/sdi.12818","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T01:06:07Z","timestamp":1556759167000},"page":"463-466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Is oxidative stress an issue in peritoneal dialysis?"],"prefix":"10.1111","volume":"32","author":[{"given":"Stefanos","family":"Roumeliotis","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, 1st Department of Internal Medicine AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros","family":"Eleftheriadis","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, 1st Department of Internal Medicine AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilios","family":"Liakopoulos","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, 1st Department of Internal Medicine AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9036450"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg074"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.08.015"},{"key":"e_1_2_3_5_1","first-page":"3081856","article-title":"Oxidative stress in hemodialysis patients: a review of the literature","volume":"2017","author":"Liakopoulos V","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000109"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12745"},{"issue":"6","key":"e_1_2_3_8_1","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1177\/089686080802800619","article-title":"Cytotoxicity of mononuclear cells as induced by peritoneal dialysis fluids: insight into 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