{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:31:02Z","timestamp":1759336262247,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Dialysis"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The dialysis bath holds up to 90\u00a0mmHg carbon dioxide (CO<jats:sub>2<\/jats:sub>) in order to keep pH low and salts in their soluble forms. CO<jats:sub>2<\/jats:sub> crosses the dialyzer membrane and diffuses to patients. In post\u2010dilution on\u2010line hemodiafiltration (HDF) many liters of CO<jats:sub>2<\/jats:sub>\u2010containing dialysis bath \u2013 in the form of infusate \u2013 are delivered directly to patients bypassing the filtering membrane, but the precise amount of CO<jats:sub>2<\/jats:sub> delivered is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To gain insights on this issue 18 outpatients undergoing their regular on\u2010line HDF were investigated by means of blood gas analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Arterial pre\u2010dialysis samples show slight hypocapnia (35.40\u00a0\u00b1\u00a03.22\u00a0mmHg) consistent with the secondary compensatory response to metabolic acidosis. In blood coming back to patients (venous line of extracorporeal circuit) pCO<jats:sub>2<\/jats:sub> doubled, amounting to 69\u00a0\u00b1\u00a05.5\u00a0mmHg (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001 with respect to pre\u2010dialysis values) hence in on\u2010line HDF a CO<jats:sub>2<\/jats:sub> gain does occur. Turning off the infusate flux pump, pCO<jats:sub>2<\/jats:sub> decreased to 63.1\u00a0\u00b1\u00a05.8\u00a0mmHg (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.004) meaning that delivery of infusate in post\u2010dilution mode significantly contributes to CO<jats:sub>2<\/jats:sub> gain, albeit by a small amount.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>On\u2010line HDF is featured by CO<jats:sub>2<\/jats:sub> delivery to patients, in part dragged by the infusate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/sdi.12911","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T09:55:05Z","timestamp":1597053305000},"page":"38-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["On the CO<sub>2<\/sub> gain in on\u2010line hemodiafiltration"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3982-1987","authenticated-orcid":false,"given":"Marco","family":"Marano","sequence":"first","affiliation":[{"name":"Unit of Nephrology and Dialysis Maria Rosaria Clinic Pompeii (Naples) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Izzo","sequence":"additional","affiliation":[{"name":"Soreben srl. Ambulatorio di Emodialisi Scafati (Salerno) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.139"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443785"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.162"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443785"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12477"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2005.00126.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441439"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1982.172"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-015-0913-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.2002.06877.x"}],"container-title":["Seminars in Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsdi.12911","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sdi.12911","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/sdi.12911","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sdi.12911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T05:33:37Z","timestamp":1693719217000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sdi.12911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,10]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/sdi.12911"],"URL":"https:\/\/doi.org\/10.1111\/sdi.12911","archive":["Portico"],"relation":{},"ISSN":["0894-0959","1525-139X"],"issn-type":[{"type":"print","value":"0894-0959"},{"type":"electronic","value":"1525-139X"}],"subject":[],"published":{"date-parts":[[2020,8,10]]},"assertion":[{"value":"2020-08-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}