{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T19:11:21Z","timestamp":1761419481528,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Dialysis"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Fluid overload and sleep apnea (SA) are known risk factors for mortality in dialysis patients. Although incidence and severity of SA were shown higher in peritoneal dialysis (PD) patients than in hemodialysis patients, data regarding the association of SA with body fluid status and mortality are limited. Therefore, the association of SA with body fluid status and mortality were investigated in a prospective cohort with patients undergoing PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study included 103 prevalent PD patients who were followed up for median 70\u00a0months. At baseline, the subjects underwent in\u2010home polysomnography, bioelectrical impedance analysis, and urea kinetics. Excessive daytime sleepiness and sleep quality were assessed using sleep questionnaires. SA was defined as apnea\/hypopnea index higher than 15 events per hour.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sleep apnea was diagnosed in 57 (55.3%) patients (SA group); the subjects had significantly higher extracellular water (10.3\u00a0\u00b1\u00a01.4 vs. 9.2\u00a0\u00b1\u00a01.8, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) and lower residual kidney function (RKF) (3.3\u00a0\u00b1\u00a03.3 vs. 5.9\u00a0\u00b1\u00a07.2, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02) compared with subjects in the non\u2010SA group. SA was significantly associated with RKF [odds ratio, 0.84; 95% confidence interval (CI), 0.73\u20130.97] in multivariable logistic regression analysis. In multivariable Cox regression models, SA was a significant predictor of mortality in PD patients (adjusted hazard ratio, 5.74; 95% CI, 1.09\u201330.31) after adjusting for well\u2010known risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sleep apnea was very common in PD patients and significantly associated with lower RKF. SA was also a novel risk predictor of mortality in PD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/sdi.12994","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T06:55:08Z","timestamp":1625554508000},"page":"146-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sleep apnea is associated with residual kidney function and mortality in patients with peritoneal dialysis: Prospective cohort study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6507-2676","authenticated-orcid":false,"given":"Shin Chan","family":"Kang","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Uijeongbu Eulji Medical Center Eulji University School of Medicine  Uijeongbu Gyeounggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6365-0428","authenticated-orcid":false,"given":"Kyoung Sook","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine NHIS Ilsan Hospital  Goyang Gyeounggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3311-6379","authenticated-orcid":false,"given":"Tae Ik","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine NHIS Ilsan Hospital  Goyang Gyeounggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sug Kyun","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine NHIS Ilsan Hospital  Goyang Gyeounggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2153-068X","authenticated-orcid":false,"given":"Ea Wha","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine NHIS Ilsan Hospital  Goyang Gyeounggi\u2010do Republic of 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