{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:01:05Z","timestamp":1747188065997,"version":"3.40.5"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Dialysis"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thyroid dysfunction and insulin resistance (IR) are common findings in patients with ESRD. We aimed to evaluate thyroid dysfunction and IR in ESRD before and after 1\u2009year of starting hemodialysis (HD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective study that recruited newly starting HD patients who fulfilled the inclusion criteria. Patients were evaluated for TSH, free T4, free T3, fasting insulin, fasting glucose, HOMA\u2010IR, serum ferritin, and hs\u2010CRP levels before starting their first dialysis session and after 1\u2009year of regular HD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010one patients have completed the 1\u2010year follow\u2010up period. After 1\u2009year of regular HD, there were statistically significant increments of hs\u2010CRP, serum ferritin, and TSH levels. On the other hand, fasting insulin level and HOMA\u2010IR showed statistically significant increments after 1\u2009year of starting HD. After 1\u2009year of regular HD, TSH level showed a positive correlation with hs\u2010CRP and serum ferritin level, while free T3 was negatively correlated with HOMA\u2010IR. On the other hand, there was a significant positive correlation between HOMA\u2010IR, hs\u2010CRP, and serum ferritin levels, while HOMA\u2010IR was negatively correlated with Kt\/V.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests overlapping complex pathogenesis of thyroid dysfunction, chronic inflammation, and IR in chronic HD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/sdi.13044","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T04:44:11Z","timestamp":1639025051000},"page":"138-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Thyroid dysfunction and insulin resistance in end\u2010stage renal disease patients before and 1\u2009year after starting maintenance hemodialysis: A prospective multicenter study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0345-779X","authenticated-orcid":false,"given":"Mona","family":"Tawfik","sequence":"first","affiliation":[{"name":"Mansoura Nephrology and Dialysis Unit, Internal Medicine Department, Faculty of Medicine Mansoura University Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha","family":"Fathy","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Talkha Central Hospital Talkha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amany A.","family":"Mousa","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Internal Medicine Department, Faculty of Medicine Mansoura University Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Ghonem","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Internal Medicine Department, Faculty of Medicine Mansoura University Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4682-2777","authenticated-orcid":false,"given":"Mostafa","family":"Abdelsalam","sequence":"additional","affiliation":[{"name":"Mansoura Nephrology and Dialysis Unit, Internal Medicine Department, Faculty of Medicine Mansoura University Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,8]]},"reference":[{"issue":"2","key":"e_1_2_9_2_1","first-page":"109","article-title":"Endocrine abnormalities in patients with chronic kidney disease","volume":"36","author":"Kuczera P","year":"2015","journal-title":"Pril (Makedon Akad Nauk Umet Odd Med Nauki)"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.13211216"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2658"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.12.009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-014-0121-6"},{"issue":"1","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.20452\/pamw.883","article-title":"Insulin resistance as a novel therapeutic target in patients with chronic kidney disease treated with dialysis","volume":"120","author":"Wesolowski P","year":"2010","journal-title":"Pol Arch Med Wewn"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.85584"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00596-009-0126-x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.4.526"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.2.8182"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-46-1-125"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0229"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2008.01.008"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08070910"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10040245"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-015-0063-9"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00800208"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12339"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12453"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12081111"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/15.5.668"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12527"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/089686089801800510"},{"issue":"5","key":"e_1_2_9_25_1","first-page":"917","article-title":"Free thyroxine, free triiodothyronine and thyroid\u2010stimulating hormone before and after hemodialysis in Saudi patients with end\u2010stage renal disease: is there any difference?","volume":"22","author":"Alsaran K","year":"2011","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197403282901301"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110067"},{"issue":"4","key":"e_1_2_9_28_1","first-page":"377","article-title":"Glucose and insulin metabolism in uremia","volume":"61","author":"Mak RH","year":"1992","journal-title":"Nephron Clin Pract"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000019900.87535.43"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/08860220903491232"},{"key":"e_1_2_9_31_1","article-title":"Insulin resistance and cardiovascular risks in different groups of hemodialysis patients: a multicenter study","author":"Duong TV","year":"2019","journal-title":"Biomed Res Int"},{"issue":"11","key":"e_1_2_9_32_1","article-title":"Study on subclinical hypothyroidism and its association with various inflammatory markers","volume":"9","author":"Gupta G","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nefro.2017.07.001"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318187c010"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00499.2002"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02874.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-015-0011-x"},{"issue":"3","key":"e_1_2_9_38_1","first-page":"1206","article-title":"The relationship between thyrotropin and low density lipoprotein cholesterol is modified by insulin sensitivity in healthy euthyroid subjects","volume":"86","author":"Bakker SJ","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_9_39_1","first-page":"1327","volume-title":"Endocrinology","author":"Jameson JL","year":"2001"},{"issue":"4","key":"e_1_2_9_40_1","first-page":"S87","article-title":"Insulin resistance in dialysis versus non dialysis end stage renal disease patients without diabetes","volume":"94","author":"Satirapoj B","year":"2011","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2015.1073053"}],"container-title":["Seminars in Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sdi.13044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/sdi.13044","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sdi.13044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T02:18:18Z","timestamp":1726280298000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sdi.13044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,8]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/sdi.13044"],"URL":"https:\/\/doi.org\/10.1111\/sdi.13044","archive":["Portico"],"relation":{},"ISSN":["0894-0959","1525-139X"],"issn-type":[{"type":"print","value":"0894-0959"},{"type":"electronic","value":"1525-139X"}],"subject":[],"published":{"date-parts":[[2021,12,8]]},"assertion":[{"value":"2021-02-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}