{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:01:07Z","timestamp":1747188067345,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:00:00Z","timestamp":1642118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100019534","name":"Science Fund for Distinguished Young Scholars of Guangxi Province","doi-asserted-by":"publisher","award":["2010GXNSFA013192"],"award-info":[{"award-number":["2010GXNSFA013192"]}],"id":[{"id":"10.13039\/501100019534","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Dialysis"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Many patients on maintenance hemodialysis (MHD) eventually suffer from cachexia. The Functional Assessment of Anorexia\/Cachexia Therapy (FAACT) is a tool used to evaluate the quality of life of patients with cachexia related to various diseases, but its suitability for use in MHD patients has yet to be verified. This study aimed to explore the validation of the FAACT in MHD patients by conducting reliability and validity tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Qualified MHD patients were selected to complete the FAACT and Kidney Disease Quality of Life Short Form 36 (KDQOL\u201036) questionnaires, and their demographic data and biochemical test results were collected from electronic medical records. Next, the Cronbach's alpha coefficient, paired sample <jats:italic>t<\/jats:italic> test and ICC were used to analyze the scale consistency. Additionally, the association between the KDQOL\u201036 and FAACT was analyzed using Bland\u2013Altman plots and Pearson correlation analysis. Finally, the patients were divided into groups to evaluate discriminant validity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 299 patients were included in this study. The Cronbach's alpha coefficients of the FAACT and its anorexia\u2013cachexia subscale (ACS) were 0.904 and 0.842, respectively, and their ICC exceeded 0.90. The correlation coefficients between the FAACT and its items ranged from 0.146 to 0.631, and the correlation coefficients between the FAACT and KDQOL\u201036 dimensions ranged from 0.446 to 0.617. The Bland\u2013Altman plots between the FAACT and KDQOL\u201036 showed that only 3.3% of the points were outside the 95% limits of agreement. The effects of cachexia status (present or absent) on FAACT and ACS scores had effect sizes of 0.54 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001) and 0.60 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001), respectively. The FAACT and ACS also significantly discriminated between patients with and without inflammation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The FAACT and ACS have acceptable reliability and validity in MHD patients and are suitable for measuring the quality of life of MHD patients with cachexia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/sdi.13053","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T07:58:46Z","timestamp":1642233526000},"page":"330-336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Validation of the functional assessment of anorexia\/cachexia therapy instrument to assess quality of life in maintenance hemodialysis patients with cachexia"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3982-8046","authenticated-orcid":false,"given":"Zhen","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9734-2725","authenticated-orcid":false,"given":"Yixin","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Nursing Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haizhen","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baolin","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of 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