{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:01:07Z","timestamp":1747188067586,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Dialysis"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The aim of our study is to compare clotting of CRRT filters in patients with COVID\u201019\u2010associated AKI versus septic shock\u2010associated AKI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study of adult ICU patients with COVID\u201019 compared to those with septic shock admitted to a tertiary hospital April\u2013October 2020. Independent <jats:italic>t<\/jats:italic> test and chi\u2010square test used to determine statistical significance of CRRT filter clotting between the two groups. Time\u2010to\u2010event data analyzed with Kaplan\u2013Meier curves. Analyses performed on Microsoft Excel and MedCalc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven ICU patients with AKI requiring CRRT were included, 13 with COVID\u201019 and 14 non\u2010COVID\u201019 patients with septic shock. The mean half\u2010life of CRRT hemofilter was similar in COVID\u201019 patients compared to non\u2010COVID\u201019 patients (27.4 vs. 27.5\u00a0h, <jats:italic>p<\/jats:italic>\u2009=\u20090.79). The number of CRRT hemofilter changes per day was similar in both groups (0.6 filter changes per day, <jats:italic>p<\/jats:italic>\u2009=\u20090.84). However, significantly more patients with COVID\u201019 were on systemic heparin (69% vs. 13%, <jats:italic>p<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found that COVID\u201019 patients with AKI requiring CRRT had similar CRRT hemofilter half\u2010life compared with sepsis\u2010associated AKI patients with use of regional citrate and systemic heparin. Further studies are needed to find which methods of anticoagulation are optimal in patients with COVID\u201019 infection with AKI requiring CRRT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/sdi.13061","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T04:50:25Z","timestamp":1644468625000},"page":"325-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Regional citrate and systemic heparin are adequate to maintain filter half\u2010life for COVID\u201019 patients on continuous renal replacement therapy"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4186-0667","authenticated-orcid":false,"given":"Cassandra","family":"Chiao","sequence":"first","affiliation":[{"name":"Department of Medicine University of Wisconsin\u2010Madison School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"Faust","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Wisconsin\u2010Madison School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tripti","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Wisconsin\u2010Madison School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.05.006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1963"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.04.003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14768"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30211\u20107"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14830"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr480"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02500310"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020030276"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/2021.03.10.21252749"}],"container-title":["Seminars in Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sdi.13061","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/sdi.13061","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sdi.13061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T03:37:14Z","timestamp":1692848234000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sdi.13061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,9]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/sdi.13061"],"URL":"https:\/\/doi.org\/10.1111\/sdi.13061","archive":["Portico"],"relation":{},"ISSN":["0894-0959","1525-139X"],"issn-type":[{"type":"print","value":"0894-0959"},{"type":"electronic","value":"1525-139X"}],"subject":[],"published":{"date-parts":[[2022,2,9]]},"assertion":[{"value":"2021-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}