{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:51:53Z","timestamp":1785322313163,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["945207"],"award-info":[{"award-number":["945207"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016238","name":"Ministerie van Economische Zaken en Klimaat","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016238","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002997","name":"Nierstichting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002997","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Dialysis"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinical application of continuous flow peritoneal dialysis (CFPD) has been explored since the 1960s, but despite anticipated clinical benefits, CFPD has failed to gain a foothold in clinical practice, among others due to the typical use of two catheters (or a dual\u2010lumen catheter) and large dialysate volumes required per treatment. Novel systems applying CFPD via the existing single\u2010lumen catheter using rapid dialysate cycling may solve one of these hurdles. Novel on\u2010demand peritoneal dialysate generation systems and sorbent\u2010based peritoneal dialysate regeneration systems may considerably reduce the storage space for peritoneal dialysate and\/or the required dialysate volume. This review provides an overview of current evidence on CFPD in vivo. The available (pre)clinical evidence on CFPD is limited to case reports\/series with inherently nonuniform study procedures, or studies with a small sample size, short follow\u2010up, and no hard endpoints. Small solute clearance appears to be higher in CFPD compared to conventional PD, in particular at dialysate flows \u2265100\u2009mL\/min using two single\u2010lumen catheters or a double\u2010lumen catheter. Results of CFPD using rapid cycling via a single\u2010lumen catheter are too preliminary to draw any conclusions. Continuous addition of glucose to dialysate with CFPD appears to be effective in reducing the maximum intraperitoneal glucose concentration while increasing ultrafiltration efficiency (mL\/g absorbed glucose). Patient tolerance may be an issue since abdominal discomfort and sterile peritonitis were reported with continuous circulation of the peritoneal dialysate. Thus, well\u2010designed clinical trials of longer duration and larger sample size, in particular applying CFPD via the existing catheter, are urgently required.<\/jats:p>","DOI":"10.1111\/sdi.13097","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T02:31:23Z","timestamp":1654137083000},"page":"481-497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evidence on continuous flow peritoneal dialysis: A review"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9953-5069","authenticated-orcid":false,"given":"Joost C.","family":"de Vries","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaike K.","family":"van Gelder","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Cappelli","sequence":"additional","affiliation":[{"name":"Surgical, Medical, Dental, Morphology Sciences, Transplant, Oncology and Regenerative Medicine Department, Division of Nephrology University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Bajo Rubio","sequence":"additional","affiliation":[{"name":"Nephrology Service, Hospital Universitario La Paz, Institute for Health Research (IdiPAZ), IRSIN, REDinREN  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne C.","family":"Verhaar","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin G. F.","family":"Gerritsen","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/J.ACKD.2011.09.001"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/J.1523\u20101755.2002.00505.X"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/SJ.KI.5002600"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/SJ.KI.5000382"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/J.1523\u20101755.2001.00969.X"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/NDT\/GFY340"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/J.1523\u20101755.2003.08801.X"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1251046"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506324"},{"key":"e_1_2_12_11_1","unstructured":"Heimb\u00fcrgerO MartusG WilkieM et al.Increased peritoneal ultrafiltration at a lower metabolic cost during steady concentration PD.ISPD EuroPD2021 Virtual Meeting Book of Abstracts:116.2021. 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