{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T12:37:15Z","timestamp":1776861435516,"version":"3.51.2"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Dialysis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Recent studies report that latent tuberculosis infection (LTBI) may lead to an increased risk of cardiovascular disease (CVD) that led us to hypothesize that LTBI may play an important role in major adverse cardiovascular events (MACE) in dialysis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010center retrospective cohort study was conducted. A total of 270 patients undergoing hemodialysis or peritoneal dialysis more than 3\u2009months were included. The interferon enzyme\u2010linked immunospot (IFN\u2010\u03b3 ELISPOT) assay was used for the diagnosis of LTBI. Primary endpoints were MACE, including all\u2010cause death and acute coronary syndrome (ACS). The association between LTBI and MACE was examined using multivariate Cox proportional hazards regression after adjusting for covariates and Kaplan\u2013Meier survival analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our study, the patients were classified into LTBI (<jats:italic>n\u2009=<\/jats:italic>\u00a047) or non\u2010LTBI (<jats:italic>n\u2009=<\/jats:italic>\u00a0223) groups. Independent risk factors for LTBI in dialysis population were prior tuberculosis (TB) history (odds ratio [OR] 4.817 [1.064\u201322.306]), tobacco use (OR 2.903 [1.155\u20137.299]), and older age (OR 1.027 [1.002\u20131.053]). After a median follow\u2010up of 39\u2009months, the incidence of active TB was 6.4% versus 0% in dialysis patients with and without LTBI, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.005). Multivariate Cox analysis showed that LTBI was significantly associated with MACE (hazard\u00a0ratio\u00a0[HR] 2.540 [1.490\u20134.350]) after adjustment for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prior TB history, tobacco use, and the elderly can be used to select cost\u2010effective LTBI screening target groups in dialysis patients. LTBI is not only closely related to active TB but also an independent risk factor for higher incidence of MACE in dialysis population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/sdi.13150","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T05:21:25Z","timestamp":1677216085000},"page":"59-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Risk factors and prognosis for latent tuberculosis infection in dialysis patients: A retrospective cohort study at a single tertiary care center"],"prefix":"10.1111","volume":"37","author":[{"given":"Yun","family":"Xia","sequence":"first","affiliation":[{"name":"Renal Division Peking University Shenzhen Hospital  Shenzhen China"},{"name":"Renal Division Shenzhen Luohu District Traditional Chinese Medicine Hospital  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuxia","family":"Fan","sequence":"additional","affiliation":[{"name":"Renal Division The Eighth Affiliated Hospital, Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory for Diagnosis &amp; Treatment of Emerging Infectious Diseases The Affiliated Shenzhen Third Hospital  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Statistics and Data Science Southern University of Science and Technology  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Huang","sequence":"additional","affiliation":[{"name":"Renal Division Peking University Shenzhen Hospital  Shenzhen 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