{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:28:06Z","timestamp":1790958486144,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Dialysis"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients with end\u2010stage renal disease (ESRD) have an increased risk of cardiovascular disease, but interpreting cardiac troponin is difficult in this population. The effect of renal replacement therapy (RRT) is important to consider when interpreting serial cardiac troponin T (cTnT) results for patients with ESRD suspected of acute coronary syndrome (ACS). The aim of this systematic review is to answer how low\u2010flux hemodialysis (LF\u2010HD), high\u2010flux hemodialysis (HF\u2010HD), and hemodiafiltration (HDF) affect the blood concentration of high\u2010sensitive cardiac troponin T (hs\u2010cTnT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Several databases were searched and identified records were evaluated independently by two of the authors. Pre\u2010 and postdialysis hs\u2010cTnT concentrations together with other relevant data were extracted from the included studies. The quality (potential bias and applicability issues) were assessed for each of the included studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The literature search identified 2,540 records and 15 studies were included. The relative pre\u2010 to postdialysis change of hs\u2010cTnT varied from \u221241 to 29%. LF\u2010HD increased the hs\u2010cTnT concentration with relative changes between 2 and 17%. HDF decreased the concentration with relative changes from \u221241% to \u22129%. Both increases and decreases were seen for HF\u2010HD (\u221216% to 12%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion\/Conclusion<\/jats:title><jats:p>In this systematic review, we found LF\u2010HD to increase the hs\u2010cTnT concentration and HDF to decrease the concentration. Results for HF\u2010HD and unspecified HD are more heterogeneous. Because of the differences between the included studies, a meta\u2010analysis was not meaningful. This systematic review can help with the assessment of patients with ESRD suspected of ACS in relation to hemodialysis\/HDF treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/sdi.13178","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:43:22Z","timestamp":1696229002000},"page":"110-116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The short\u2010term effect of hemodialysis on the level of high\u2010sensitive cardiac troponin T \u2014 A systematic review"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8652-0316","authenticated-orcid":false,"given":"Michael Mejer","family":"Hunderup","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry and Immunology University Hospital of Southern Denmark  Aabenraa Denmark"},{"name":"Department of Clinical Biochemistry and Immunology Lillebaelt Hospital  Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Dominik","family":"Kampmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Hospital of Southern Denmark  Sonderborg Denmark"},{"name":"Institute of Regional Health Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans Brandt","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Hospital of Southern Denmark  Sonderborg Denmark"},{"name":"Institute of Regional Health Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Hafsund","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Hospital of Southern Denmark  Sonderborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.678342"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.08.026"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000617"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2016.011"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2016.1230886"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2013.207142"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2016.05.015"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy179"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2012.200543"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2016.261644"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2019.11.035"},{"key":"e_1_2_8_13_1","unstructured":"Covidence systematic review software Veritas Health Innovation Melbourne Australia. 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