{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:57:55Z","timestamp":1789423075763,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Dialysis"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Longitudinal evolution of peritoneal protein loss (PPL), a reflection of hydrostatic pressure\u2013driven leak of plasma proteins through the large\u2010pore pathway, is not clear. Time on PD causes loss of mesothelial cells, vasculopathy, and increased thickness of the submesothelial fibrous layer. Are these structural changes associated with progressive increase of PPL, in a parallel with the rise in the D\/P creatinine? The aim of the present study was to identify longitudinal changes of PPL over time. This single\u2010center, longitudinal study included 52 peritoneal dialysis (PD) patients with a median follow\u2010up of 26.5\u2009months, evaluated at two different time points with a minimum interval of 6\u2009months. Repeated measures analysis was performed using paired sample <jats:italic>t<\/jats:italic>\u2010test or the nonparametric Wilcoxon signed\u2010rank test, depending on the distribution. After a median interval of 15.5\u2009months, lower levels of residual renal function and urine volume, lower Kt\/V, and creatinine clearance were found. D\/P creatinine and PPL were stable, but a decrease in ultrafiltration was present. Systemic inflammation, nutrition, and volume overload showed no significant change with time on PD. Analysis of a subpopulation with over 48\u2009months between initial and subsequential assessment (<jats:italic>n<\/jats:italic>\u2009=\u200911) showed again no difference in inflammation, nutritional and hydration parameters from baseline, but importantly PPL decreased after more than 4\u2009years on PD (mean difference 1.2\u2009g\/24, <jats:italic>p<\/jats:italic>\u2009=\u20090.033). D\/P creatinine and dip of sodium remained unchanged. The absence of deleterious effects of time on PD is reassuring, pointing to the benefit of updated PD prescription, including the standard use of more biocompatible solutions towards membrane preservation and adjusted prescription avoiding overhydration and inflammation while maintaining nutritional status. After controlling for confounders, PPL may act as a biomarker of acquired venous vasculopathy, even if small pore fluid transport rates and free water transport are preserved.<\/jats:p>","DOI":"10.1111\/sdi.13194","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T09:19:16Z","timestamp":1709198356000},"page":"242-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Peritoneal Protein Loss With Time in Peritoneal Dialysis"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9627-908X","authenticated-orcid":false,"given":"Anabela","family":"Malho\u00a0Guedes","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Nefrologia Centro Hospitalar Universit\u00e1rio do Algarve  Faro Portugal"},{"name":"Unidade Multidisciplinar de Investiga\u00e7\u00e3o Biom\u00e9dica (UMIB), Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, e ITR \u2010 Laboratory for Integrative and Translational Research in Population Health Universidade do Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Cal\u00e7as","family":"Marques","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Nefrologia Centro Hospitalar Universit\u00e1rio do Algarve  Faro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Teresa","family":"Domingos","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Nefrologia Centro Hospitalar Universit\u00e1rio do Algarve  Faro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9u","family":"Laranjo","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Nefrologia Centro Hospitalar Universit\u00e1rio do Algarve  Faro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Silva","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Nefrologia Centro Hospitalar Universit\u00e1rio do Algarve  Faro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anabela","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Unidade Multidisciplinar de Investiga\u00e7\u00e3o Biom\u00e9dica (UMIB), Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, e ITR \u2010 Laboratory for Integrative and Translational Research in Population Health Universidade do Porto  Porto Portugal"},{"name":"Servi\u00e7o de Nefrologia Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond T.","family":"Krediet","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Amsterdam University Medical Centre  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2018.00138"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1984.167"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.884061"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2018.00016"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04420413"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.885802"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/08968608221075102"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2014.00215"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2011.00175"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000525502"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00105"},{"issue":"6","key":"e_1_2_9_13_1","first-page":"686","article-title":"Relationship of TNF\u2010Alpha, Interleukin\u20106, and Prostaglandins to Peritoneal Permeability for Macromolecules During Longitudinal Follow\u2010Up of Peritonitis in Continuous Ambulatory Peritoneal Dialysis","volume":"122","author":"Zemel D.","year":"1993","journal-title":"The Journal of Laboratory and Clinical Medicine"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013030314"},{"issue":"1","key":"e_1_2_9_15_1","first-page":"19","article-title":"Kinetics of Peritoneal Dialysis With Glycerol and Glucose as Osmotic Agents","volume":"33","author":"Lindholm B.","year":"1987","journal-title":"ASAIO Transactions"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000314544"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/089686080602600109"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.653807"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000516531"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000498841"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn595"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255\u2010014\u20100744\u20108"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2012.01063"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.6.1541"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.5414\/CN109596"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1993.188"}],"container-title":["Seminars in Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sdi.13194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T04:16:46Z","timestamp":1714018606000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sdi.13194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,29]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/sdi.13194"],"URL":"https:\/\/doi.org\/10.1111\/sdi.13194","archive":["Portico"],"relation":{},"ISSN":["0894-0959","1525-139X"],"issn-type":[{"value":"0894-0959","type":"print"},{"value":"1525-139X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,29]]},"assertion":[{"value":"2023-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}