{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:06:50Z","timestamp":1787170010660,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017357","name":"Science and Technology Projects of Fujian Province","doi-asserted-by":"publisher","award":["2022D028"],"award-info":[{"award-number":["2022D028"]}],"id":[{"id":"10.13039\/100017357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900365"],"award-info":[{"award-number":["81900365"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Dialysis"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Calcium\u2010free (Ca\u2010free) solutions are theoretically the most ideal for regional citrate anticoagulation (RCA) in continuous renal replacement therapy (CRRT). However, the majority of medical centers in China had to make a compromise of using commercially available calcium\u2010containing (Ca\u2010containing) solutions instead of Ca\u2010free ones due to their scarcity. This study was designed to probe into the potential of Ca\u2010containing solution as a secure and efficient substitution for Ca\u2010free solutions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective, randomized single\u2010center trial, 99 patients scheduled for CRRT were randomly assigned in a 1:1:1 ratio to one of three treatment groups: continuous veno\u2010venous hemodialysis Ca\u2010free dialysate (CVVHD Ca\u2010free) group, continuous veno\u2010venous hemodiafiltration calcium\u2010free dialysate (CVVHDF Ca\u2010free) group, and continuous veno\u2010venous hemodiafiltration Ca\u2010containing dialysate (CVVHDF Ca\u2010containing) group at cardiac intensive care unit (CICU). The primary endpoint was the incidence of metabolic complications. The secondary endpoints included premature termination of treatment, thrombus of filter, and bubble trap after the process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of citrate accumulation (18.2% vs. 12.1% vs. 21.2%) and metabolic alkalosis (12.1% vs. 0% vs. 9.1%) did not significantly differ among three groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05 for both). The incidence of premature termination was comparable among the groups (18.2% vs. 9.1% vs. 9.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.582). The thrombus level of the filter and bubble trap was similar in the three groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05 for all).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In RCA\u2010CRRT for CICU population, RCA\u2010CVVHDF with Ca\u2010containing solutions and traditional RCA with Ca\u2010free solutions had a comparable safety and feasibility.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ChiCTR2100048238 in the Chinese Clinical Trial Registry.\n                    <\/jats:p>\n                  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