{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T03:54:34Z","timestamp":1781495674303,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"vor","delay-in-days":97,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Dialysis"],"published-print":{"date-parts":[[2025,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Renal replacement therapy (RRT) is crucial for end\u2010stage renal disease, yet its pulmonary effects remain unclear. Fractional exhaled nitric oxide (FeNO) serves as a biomarker for airway inflammation. This study evaluates FeNO levels in hemodialysis (HD) and peritoneal dialysis (PD) patients and their relationship with pulmonary function.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n RRT patients aged 18\u201365, followed for at least 2\u2009years in our nephrology clinic, were included. FeNO tests were performed after routine blood sampling. The study comprised 110 patients: 50 HD, 30 PD, and 30 controls.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n FeNO levels before and after dialysis were statistically significantly higher in HD patients compared to PD patients (\n p<\/jats:italic>\n \u2009=\u2009<\u20090.001 for both). Exhaled NO levels measured in the control group were 7.6\u2009\u00b1\u20095.2\u2009ppb and were statistically significantly lower compared to HD patients before and after dialysis (\n p<\/jats:italic>\n \u2009=\u2009<\u20090.001 for both). A negative correlation was observed between FeNO and FEV1 and FVC percent (\n R<\/jats:italic>\n \u2009=\u2009\u22120.807,\n p<\/jats:italic>\n \u2009=\u20090.01;\n R<\/jats:italic>\n \u2009=\u2009\u22120.801,\n p<\/jats:italic>\n \u2009=\u20090.01, respectively). A positive correlation was observed between exhaled NO levels before and after dialysis and \u0394FVC, \u0394FEV1, and \u0394PEF25\u201375 (\n R<\/jats:italic>\n \u2009=\u20090.74,\n p<\/jats:italic>\n \u2009=\u20090.01;\n R<\/jats:italic>\n \u2009=\u20090.74,\n p<\/jats:italic>\n \u2009=\u20090.01;\n R<\/jats:italic>\n \u2009=\u20090.89,\n p<\/jats:italic>\n \u2009=\u20090.01, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This study showed that FeNO levels were significantly higher in HD patients before and after RRT compared to PD and healthy controls, suggesting a greater impact of HD on airway inflammation. FeNO measurement may serve as a biomarker for monitoring pulmonary health in RRT patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/sdi.70011","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T04:49:58Z","timestamp":1765169398000},"page":"340-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Renal Replacement Therapy on FeNO Levels and Pulmonary Function in End\u2010Stage Renal Disease Patients"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6048-1462","authenticated-orcid":false,"given":"Bu\u011fra","family":"Kerget","sequence":"first","affiliation":[{"name":"Department of Pulmonary Diseases Ataturk University School of Medicine Yakutiye Erzurum Turkey"},{"name":"Department of Pulmonary Diseases Aksaray University School of Medicine Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130smail","family":"\u00c7\u0131nar","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Ataturk University School of Medicine Yakutiye Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eda","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Erzurum City Hospital Yakutiye Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Sevin\u00e7","sequence":"additional","affiliation":[{"name":"Department of Nephrology Ataturk University School of Medicine Yakutiye Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7821-8275","authenticated-orcid":false,"given":"Edip","family":"Erku\u015f","sequence":"additional","affiliation":[{"name":"Department of Nephrology Erzurum City Hospital Yakutiye Erzurum Turkey"},{"name":"Department of Nephrology Konya City Hospital Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1081\/JDI-120039526"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02719668"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11111012"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132008001100004"},{"issue":"12","key":"e_1_2_12_6_1","first-page":"776","article-title":"Anemia and Hypoalbuminemia at Initiation of Hemodialysis as Risk Factor for Survival of Dialysis Patients","volume":"19","author":"Anees M.","year":"2009","journal-title":"Journal of the College of Physicians and Surgeons\u2013Pakistan"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V75728"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2013.830225"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.46.6.424"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00.16478100"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000034073"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.9120-11ST"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jep237"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1590ST"},{"issue":"10","key":"e_1_2_12_15_1","first-page":"1","article-title":"Kidney: A Review on End Stage Renal Disease, Dialysis and Transplant","volume":"2","author":"Palleti S. K.","year":"2023","journal-title":"International Clinical and Medical Case Reports Journal"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V102354"},{"issue":"3","key":"e_1_2_12_17_1","first-page":"214","article-title":"Acute Effects of Hemodialysis on Pulmonary Function in Patients With End\u2010Stage Renal Disease","volume":"4","author":"Rahgoushai R.","year":"2010","journal-title":"Iranian Journal of Kidney Diseases"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/014107688507801012"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/11.11.2269"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.135003"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516-3180.2017.0179150817"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1000839"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(97)90491-1"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn751"},{"key":"e_1_2_12_25_1","first-page":"2337","article-title":"The Correlation of Interleukin\u20106, Malnutrition Inflammation Score and Asymmetric Dimethylarginine in Chronic Kidney Disease Patients Undergoing Routine Hemodialysis. Open Access Macedonian","volume":"10","author":"Palar S.","year":"2022","journal-title":"Journal of Medical Sciences"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.897480"}],"container-title":["Seminars in Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sdi.70011","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/sdi.70011","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sdi.70011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T03:30:51Z","timestamp":1781494251000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sdi.70011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":25,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/sdi.70011"],"URL":"https:\/\/doi.org\/10.1111\/sdi.70011","archive":["Portico"],"relation":{},"ISSN":["0894-0959","1525-139X"],"issn-type":[{"value":"0894-0959","type":"print"},{"value":"1525-139X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}