{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:28:15Z","timestamp":1790310495667,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":126,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Dialysis"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Dialysis improves survival in kidney failure but does not effectively remove larger uremic toxins, contributing to persistent symptoms like restless legs syndrome (RLS). High\u2010volume hemodiafiltration (HDF) has improved these issues, but refractory cases may require combined therapies with hemoadsorption (HA). We present a patient with refractory RLS treated with HDF plus hemoadsorption using Jafron HA130 cartridges. The\n                    <jats:italic>\u03b2<\/jats:italic>\n                    2 microglobulin (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    2M) reduction ratio was higher during HDF+HA (76.4% [75.8\u201377.8] vs. 72.9% [71.1\u201373.2]), with further improvement at Q\n                    <jats:sub>B<\/jats:sub>\n                    &gt; 400 ml\/min (77.6% [77.2\u201379.4]). Despite similar baseline\n                    <jats:italic>\u03b2<\/jats:italic>\n                    2M levels, the patient's RLS score dropped from 32 to 0 points. Adding once\u2010weekly hemoadsorption to high\u2010volume HDF using HA130 adsorption may enhance refractory uremic symptom management, particularly at higher Q\n                    <jats:sub>B<\/jats:sub>\n                    values. Given the scarce literature on this approach, our case highlights its potential benefits for dialysis patients with persistent uremic symptoms.\n                  <\/jats:p>","DOI":"10.1111\/sdi.70014","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:19:47Z","timestamp":1767676787000},"page":"357-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Utility of Adding Once\u2010Weekly Hemoadsorption to High\u2010Volume Hemodiafiltration for Refractory Restless Legs Syndrome: A Clinical Case Report"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1338-0503","authenticated-orcid":false,"given":"Cristian","family":"Pedreros\u2010Rosales","sequence":"first","affiliation":[{"name":"Departamento de Medicina Interna, Facultad de Medicina Universidad de Concepci\u00f3n  Concepci\u00f3n Chile"},{"name":"Nephrology Service Hospital Las Higueras  Talcahuano Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1696-9997","authenticated-orcid":false,"given":"Gonzalo","family":"Ram\u00edrez\u2010Guerrero","sequence":"additional","affiliation":[{"name":"Nephrology Service Hospital Las Higueras  Talcahuano Chile"},{"name":"Nephrology and Dialysis Unit Carlos Van Buren Hospital  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4735-5856","authenticated-orcid":false,"given":"Hans","family":"M\u00fcller\u2010Ortiz","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Facultad de Medicina Universidad de Concepci\u00f3n  Concepci\u00f3n Chile"},{"name":"Nephrology Service Hospital Las Higueras  Talcahuano Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Alarc\u00f3n\u2010Fuentes","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Facultad de Medicina Universidad de Concepci\u00f3n  Concepci\u00f3n Chile"},{"name":"Nephrology Service Hospital Las Higueras  Talcahuano Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Calder\u00f3n\u2010Salazar","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Facultad de Medicina Universidad de Concepci\u00f3n  Concepci\u00f3n Chile"},{"name":"Nephrology Service Hospital Las Higueras  Talcahuano Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101755.2003.00924.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2215\/cjn.02660221"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs530"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins15090531"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra071313"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq681"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u2010139x.2006.00157.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000533469"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1389\u20109457(03)00010\u20108"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000527953"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493523"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2015.03.025"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000518857"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000525952"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14954"}],"container-title":["Seminars in Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sdi.70014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/sdi.70014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sdi.70014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T03:31:08Z","timestamp":1781494268000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sdi.70014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":15,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/sdi.70014"],"URL":"https:\/\/doi.org\/10.1111\/sdi.70014","archive":["Portico"],"relation":{},"ISSN":["0894-0959","1525-139X"],"issn-type":[{"value":"0894-0959","type":"print"},{"value":"1525-139X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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