{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:21:18Z","timestamp":1787757678300,"version":"build-2784847793"},"reference-count":6,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Dialysis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Exit\u2010site granuloma is a frequent and challenging complication in patients undergoing peritoneal dialysis, predisposing to exit\u2010site infections. Recent evidence suggests a potential role for topical timolol in promoting regression of granulomatous tissue. We report two patients on continuous ambulatory peritoneal dialysis who developed exit\u2010site granulomas. Both patients were treated with topical 0.5% timolol maleate ophthalmic solution applied locally to the exit site three times weekly as part of routine exit\u2010site care. Clinical response was monitored using serial photographs. Complete resolution of the granuloma was achieved within 3\u2009weeks in one patient and within 2\u2009months in the other. Neither patient developed local or systemic adverse effects, and no exit\u2010site infections occurred during treatment. Topical 0.5% timolol maleate may represent a safe, non\u2010invasive, and effective treatment option for peritoneal dialysis exit\u2010site granulomas. Larger studies are warranted to establish its efficacy in larger cohorts.<\/jats:p>","DOI":"10.1111\/sdi.70039","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T03:01:55Z","timestamp":1784516515000},"page":"204-206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Topical Timolol for Peritoneal Dialysis Catheter Exit\u2010Site Granulomas: First Report of Successful Use in CAPD Patients"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6725-4545","authenticated-orcid":false,"given":"Veenaa\u00a0Manjari","family":"S","sequence":"first","affiliation":[{"name":"Department of Nephrology Medway Hospitals  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2983-4554","authenticated-orcid":false,"given":"Rajeevalochana","family":"Parthasarathy","sequence":"additional","affiliation":[{"name":"Department of Nephrology Medway Hospitals  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashanth","family":"N","sequence":"additional","affiliation":[{"name":"Department of Nephrology Medway Hospitals  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavadharani","family":"Saravanan","sequence":"additional","affiliation":[{"name":"Department of Nephrology Medway Hospitals  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemanath","family":"Krishnamoorthy","sequence":"additional","affiliation":[{"name":"Department of Nephrology Medway Hospitals  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2025.01.040"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/08968608231172740"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jorc.12358"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.52768\/2766-7820\/3104"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12217"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.25259\/IJDVL_565_20"}],"container-title":["Seminars in Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sdi.70039","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/sdi.70039","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sdi.70039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:46:40Z","timestamp":1787755600000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sdi.70039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/sdi.70039"],"URL":"https:\/\/doi.org\/10.1111\/sdi.70039","archive":["Portico"],"relation":{},"ISSN":["0894-0959","1525-139X"],"issn-type":[{"value":"0894-0959","type":"print"},{"value":"1525-139X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}