{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:14:25Z","timestamp":1788398065390,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Dialysis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hemodialysis (HD) catheters carry a high risk of life\u2010threatening bloodstream infections and failure. Antimicrobial lock solutions (ALS) are used to reduce this risk, but their overall efficacy on key outcomes like infection rates and catheter survival requires comprehensive evaluation. This systematic review and meta\u2010analysis assess the impact of ALS on preventing catheter\u2010related bloodstream infections (including incidence and density) and on improving catheter survival. A systematic search was conducted across the databases of PubMed, Embase, Scopus, Cochrane Library, and Google Scholar. A meta\u2010analysis was conducted using STATA software. A total of 1183 studies were screened based on title and abstract, and further 282 studies were evaluated in full text. Eventually, 14 studies with 15 treatment arms were included. Key outcomes including central line\u2010associated bloodstream infection (CLABSI), exit infection, and catheter\u2010free survival were conducted separately. ALS demonstrated statistically significant benefits on CLABSI infection and catheter\u2010free survival compared to nonantimicrobial solutions, showing a reduction in CLABSI density with a pooled log odd ratio (logOR) of \u22121.29 (95% CI: \u22121.59 to \u22120.99), lower CLABSI rates (pooled logOR\u2009=\u2009\u22121.50, 95% CI: \u22121.85 to \u22121.15), and improved catheter\u2010free survival with log hazard ratio (logHR) of \u22121.11 (95% CI: \u22121.41 to \u22120.8). Consistent treatment effects were observed across all lock types with no significant heterogeneity detected. ALS demonstrate statistically significant and clinically important efficacy in reducing CLABSI incidence and density while improving catheter survival in HD patients, establishing them as an essential preventive strategy in clinical practice.<\/jats:p>","DOI":"10.1111\/sdi.70046","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:30:46Z","timestamp":1788395446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Antimicrobial Lock Solutions on Central Line\u2010Associated Bloodstream Infection and Catheter Survival in Hemodialysis Patients: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9879-6144","authenticated-orcid":false,"given":"Jinghua","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nursing, Faculty of Medicine and Health Sciences Universiti Putra Malaysia  Serdang Malaysia"},{"name":"Department of Nursing Chengde Central Hospital  Chengde Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6224-1083","authenticated-orcid":false,"given":"Jianpeng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Hebei Key Laboratory of Nerve Injury and Repair Chengde Medical University  Chengde Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9373-5791","authenticated-orcid":false,"given":"Haihong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychology Chengde Medical University  Chengde Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5273-2700","authenticated-orcid":false,"given":"KimGeok","family":"Soh","sequence":"additional","affiliation":[{"name":"Department of Sports Studies, Faculty of Educational Studies Universiti Putra Malaysia  Serdang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7079-6572","authenticated-orcid":false,"given":"Qingmei","family":"Ju","sequence":"additional","affiliation":[{"name":"Emergency General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2404-828X","authenticated-orcid":false,"given":"KimLam","family":"Soh","sequence":"additional","affiliation":[{"name":"Department of Nursing, Faculty of Medicine and Health Sciences Universiti Putra Malaysia  Serdang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8572-2632","authenticated-orcid":false,"given":"Xianling","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Hebei Key Laboratory of Nerve Injury and Repair Chengde Medical University  Chengde Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"issue":"3","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/23120053.2016.1156811","article-title":"Efficacy of Antimicrobial Lock Solutions in Preventing Catheter\u2010Related Blood Stream Infection in Haemodialysis Patients: A Systematic Review and Meta\u2010Analysis of Prospective Randomised Controlled Trials","volume":"31","author":"Yakasai A. 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