{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:15:22Z","timestamp":1782231322181,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T00:00:00Z","timestamp":1356480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inflammatory <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">iDCM<\/jats:styled-content>) may be related to autoimmune processes. An immunoadsorption (<jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>) has been reported to improve cardiac hemodynamics. The benefit of <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> is probably related to the removal of autoantibodies. A recent study suggests additional effects of <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> on the <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cell\u2013mediated immune reactions, especially on regulatory <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs). In this prospective study, the correlation between the level of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs and improvement of myocardial contractility in response to <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">iDCM<\/jats:styled-content> was investigated. Patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a018) with <jats:styled-content style=\"fixed-case\">iDCM<\/jats:styled-content>, reduced left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) ejection fraction (&lt;35%), were enrolled for <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>. Before and 6\u00a0months after <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> LV<\/jats:styled-content> systolic function was assessed by echocardiography, and blood levels of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs were quantified by <jats:styled-content style=\"fixed-case\">FACS<\/jats:styled-content> analysis. Patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) with chronic ischaemic heart failure and comparable reduced <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content> served as controls. <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> improved <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content> in 12 of 18 patients at 6\u2010month follow\u2010up. These patients were classified as \u2018<jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> responder\u2019. In 6 patients, <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content> remained unchanged. At baseline, <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> responder and non\u2010responder subgroups showed similar values for <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein, white blood cells, lymphocytes and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> helper cells, but they differ for the number of circulating Tregs (responder: 2.32\u00a0\u00b1\u00a01.38% versus non\u2010responder: 4.86\u00a0\u00b1\u00a00.28%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Tregs increased significantly in the <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> responders, but remained unchanged in the <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> non\u2010responders. In patients with ischaemic cardiomyopathy, none of these values changed over time. A low level of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs in patients with chronic <jats:styled-content style=\"fixed-case\">iDCM<\/jats:styled-content> may characterize a subset of patients who do best respond to <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> therapy.<\/jats:p>","DOI":"10.1111\/sji.12000","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T04:02:56Z","timestamp":1348459376000},"page":"54-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The Number of Regulatory <scp>T<\/scp> Cells Correlates with Hemodynamic Improvement in Patients with Inflammatory Dilated Cardiomyopathy After Immunoadsorption Therapy"],"prefix":"10.1111","volume":"77","author":[{"given":"D.","family":"Bulut","sequence":"first","affiliation":[{"name":"Herz\u2010 und Kreislaufzentrum der Ruhr\u2010Universit\u00e4t Standort St. 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