{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:34:18Z","timestamp":1787934858919,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T00:00:00Z","timestamp":1369180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to establish the antioxidant status and oxidative stress in adult patients with chronic idiopathic thrombocytopenic purpura (<jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>). Eighty\u2010four patients diagnosed with chronic <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> were studied. Fifty\u2010eight age\u2010matched healthy subjects were selected as controls. Serum nitrogen monoxide ( <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>), oxidized glutathione (<jats:styled-content style=\"fixed-case\">GSSG<\/jats:styled-content>), malondialdehyde (<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>), total antioxidant status (<jats:styled-content style=\"fixed-case\">TAS<\/jats:styled-content>), total oxidant status (<jats:styled-content style=\"fixed-case\">TOS<\/jats:styled-content>), superoxide dismutase(<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>), hydrogen peroxide enzyme (<jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content>), glutathione peroxidase (<jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>x), glutathione (<jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content>) were evaluated by enzyme\u2010linked\u00a0immunosorbent\u00a0assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>). It was found that serum <jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CAT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> GSH<\/jats:styled-content>\u2010Px, <jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> TAS<\/jats:styled-content> levels were significantly lower in patients with chronic <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> than controls (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), while serum <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>,\u00a0<jats:styled-content style=\"fixed-case\">GSSG<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> MDA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> TOS<\/jats:styled-content> values were significantly higher (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The number of platelet showed a negative correlation with <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> GSSG<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> MDA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> TOS<\/jats:styled-content>, respectively,while platelet number showed a positive correlation with <jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CAT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> GSH<\/jats:styled-content>\u2010Px, <jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> TAS<\/jats:styled-content>. These findings suggested that oxidants were increased and antioxidants were decreased in patients with chronic <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>, these may be prominent factors in destructing the platelet membrane. The scavenging of oxygen radical provides a theoretical basis for the treatment of <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/sji.12048","type":"journal-article","created":{"date-parts":[[2013,3,30]],"date-time":"2013-03-30T08:48:39Z","timestamp":1364633319000},"page":"482-487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Antioxidant Status and Oxidative Stress in Patients with Chronic <scp>ITP<\/scp>"],"prefix":"10.1111","volume":"77","author":[{"given":"C.\u2010Q.","family":"Jin","sequence":"first","affiliation":[{"name":"Analytical Section of Attached Hospital of Jining Medical College Jining City Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010X.","family":"Dong","sequence":"additional","affiliation":[{"name":"Analytical Section of Attached Hospital of Jining Medical College Jining City Shandong 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