{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:49:28Z","timestamp":1696225768446},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T00:00:00Z","timestamp":1373500800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The understanding of the mechanisms involved in the immune response is of significant relevance to the control of tuberculosis (<jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>), especially in individuals living with patients with <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>. To characterize the nitric oxide (<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>) production and the <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>oxp3 marker expression in this population, peripheral blood mononuclear cells of intradomiciliary contacts of individuals with pulmonary tuberculosis with (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>b, susceptible) and without (<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>b, resistant) previous history of active infection were stimulated <jats:italic>in vitro<\/jats:italic> with <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ycobacterium tuberculosis<\/jats:italic> antigen (TbAg) and with the mitogen <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>oncanavalin A for 24 and 48\u00a0h. The groups analysed did not present significant difference in the Foxp3 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression nor in the NO production. Negative correlation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.09) between NO and Foxp3 after a 48\u2010h stimulation with TbAg was observed in the STb group. In this group, after a 24\u2010h culture stimulated with TbAg (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), this same correlation was observed. In comparison with the cytokines previously studied by our group (Cavalcanti <jats:italic>et\u00a0al<\/jats:italic>., 2009), a positive correlation was observed between IL\u201010 and Foxp3 after a 48\u2010h culture of cells from communicants susceptible to tuberculosis (STb) stimulated with TbAg (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). Evaluating the entire population, a positive correlation was observed between the cytokine TNF\u2010\u03b1 and the Foxp3 marker in the cultures stimulated for 24 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) and 48 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) hours with TbAg. Therefore, considering the similarity in the exposure and the individual capacity of responding to the contact with <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>. tuberculosis<\/jats:italic>, the present study contributes to the comprehension of the immune regulation in individuals living with patients with <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/sji.12053","type":"journal-article","created":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T05:12:43Z","timestamp":1365743563000},"page":"79-84","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Foxp3 Expression and Nitric Oxide Production in Peripheral Blood Mononuclear Cells of Communicants with Pulmonary Tuberculosis"],"prefix":"10.1111","volume":"78","author":[{"given":"Y. V. 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