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The aim of this study was to investigate the possible relationship between serum IL\u201022, IL\u201017 levels, anti\u2010acetylcholine receptor antibody (anti\u2010AChR Ab) titres and clinical parameters in patients with MG. The serum IL\u201022, IL\u201017 levels and anti\u2010AChR Ab titres were tested by enzyme\u2010linked immunosorbent assay (ELISA), while the expression of IL\u201022 and IL\u201017 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>s in peripheral blood mononuclear cells (PBMC) from healthy and MG subjects were detected by quantitative real\u2010time PCR (<jats:styled-content style=\"fixed-case\">qRT<\/jats:styled-content>\u2010PCR). Furthermore, PBMC from 12 patients with generalized MG were purified and treated with recombinant human IL\u201022 (rhIL\u201022), the IL\u201017 levels of supernatant were detected by ELISA. We found that the IL\u201017 levels were significantly increased, but IL\u201022 levels were significantly decreased in the serum of patients with MG compared with healthy controls. Consistantly, a significant decrease in IL\u201022 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> levels and an increase in IL\u201017 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> levels were detected in PBMC collected from patients with MG, compared with healthy controls. A negative correlation between IL\u201022 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> in PBMC, serum IL\u201022 and serum anti\u2010AChR Ab levels was found in patients with MG. Moreover, in cultured MG PBMC treated with recombinant human IL\u201022 (rhIL\u201022), the IL\u201017 levels were decreased in a dose\u2010dependent manner. Our findings indicated a possible role of IL\u201022 as a protective factor in MG.<\/jats:p>","DOI":"10.1111\/sji.12057","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T07:15:22Z","timestamp":1366960522000},"page":"98-107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Expression of Interleukin\u201022 in Myasthenia Gravis"],"prefix":"10.1111","volume":"78","author":[{"given":"S.","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Xuzhou Medical College Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Xuzhou Medical College Xuzhou Jiangsu 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