{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:32:43Z","timestamp":1770481963381,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,21]],"date-time":"2013-07-21T00:00:00Z","timestamp":1374364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interleukin\u20107 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20107) is essential for <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cell development in the thymus and maintenance of peripheral <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells. The \u03b1\u2010chain of the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20107<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content> is polymorphic with the existence of <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s that give rise to non\u2010synonymous amino acid substitutions. We previously found an association between donor genotypes and increased treatment\u2010related mortality (<jats:styled-content style=\"fixed-case\">TRM<\/jats:styled-content>) (rs1494555<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>) and acute graft versus host disease (a<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>v<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) (rs1494555<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> and rs1494558<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>) after hematopoietic cell transplantation (<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>). Some studies have confirmed an association between rs6897932<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> and multiple sclerosis. In this study, we evaluated the prognostic significance of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20107<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u03b1 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> genotypes in 590\u2010recipient\/donor pairs that received <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010matched unrelated donor <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> for haematological malignancies. Consistent with the primary studies, the rs1494555<jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> and rs1494558<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> genotypes of the donor were associated with a<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>v<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> and chronic <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>v<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> in the univariate analysis. The <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>allele of rs6897932 was suggestive of an association with increased frequency of relapse by univariate analysis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.017) and multivariate analysis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.015). In conclusion, this study provides further evidence of a role of the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20107 pathway and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20107<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u03b1 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/sji.12077","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T11:47:14Z","timestamp":1369136834000},"page":"214-220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Polymorphism in the Interleukin\u20107 Receptor\u2010alpha and Outcome after Allogeneic Hematopoietic Cell Transplantation with Matched Unrelated Donor"],"prefix":"10.1111","volume":"78","author":[{"given":"Z.","family":"Shamim","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology sect. 7631 and Institute of Inflammation Research sect. 7541 University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Spellman","sequence":"additional","affiliation":[{"name":"Department of Immunobiology Research Center for International Blood and Marrow Transplant Research (CIBMTR) Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Haagenson","sequence":"additional","affiliation":[{"name":"Department of Immunobiology Research Center for International Blood and Marrow Transplant Research (CIBMTR) Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Wang","sequence":"additional","affiliation":[{"name":"Biostatistics\/Population Health Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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