{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T15:56:57Z","timestamp":1767887817972,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medical Research Council of Southeast Sweden (FORSS)"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sera from 84 haemodialysis (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) patients and 68 healthy blood donors were analysed with commercially available <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> techniques for fibroblast growth factor 23 (<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023), hepatocyte growth factor (<jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content>), interleukin\u20106 (Il\u20106), high\u2010sensitivity C\u2010reactive protein (hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) and soluble urokinase plasminogen activator receptor (su<jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>), to find a possible correlation of <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023 and <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content> with the earlier recognized inflammatory markers Il\u20106 and hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> or su<jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>. All patients studied had significantly elevated levels of <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023, <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content>, hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> and su<jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content> as compared to the controls. Il\u20106 and hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> correlated for patients (<jats:italic>R<\/jats:italic>\u00a0=\u00a00.6) as well as for patients and controls altogether. Ln (natural logarithm) of <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content> correlated weakly with Ln Il\u20106 and Ln <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> (<jats:italic>R<\/jats:italic> 0.28\u20130.37). Ln <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023 correlated only with Ln <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.25) in controls. Ln <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content> correlated with ln su<jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.6) in both patients and controls. Although elevated as compared to controls, we found no correlation of <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023 with the recognized inflammatory markers Il\u20106, hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>, nor <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content> or the new marker su<jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients. Ln <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content> correlated with Ln Il\u20106, Ln <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> and Ln su<jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>. Although probably involved in vessel disease, <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023 and <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content> may play other roles than acting in inflammatory vessel disease in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients. Further studies are necessary to evaluate the role of these immunological markers in chronic haemodialysis patients with atherosclerosis.<\/jats:p>","DOI":"10.1111\/sji.12082","type":"journal-article","created":{"date-parts":[[2013,5,31]],"date-time":"2013-05-31T06:19:50Z","timestamp":1369981190000},"page":"285-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Fibroblast Growth Factor 23, Hepatocyte Growth Factor, Interleukin\u20106, High\u2010Sensitivity C\u2010Reactive Protein and Soluble Urokinase Plasminogen Activator Receptor. Inflammation Markers in Chronic Haemodialysis Patients?"],"prefix":"10.1111","volume":"78","author":[{"given":"G.","family":"Almroth","sequence":"first","affiliation":[{"name":"Departments of Nephrology Link\u00f6ping University Hospital Link\u00f6ping Sweden"},{"name":"Department of Medicine and Health Sciences Link\u00f6ping University Hospital Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"L\u00f6nn","sequence":"additional","affiliation":[{"name":"Division of Clinical Medicine School of Health and Medical Sciences \u00d6rebro University \u00d6rebro Sweden"},{"name":"PEAS Institute Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Uhlin","sequence":"additional","affiliation":[{"name":"Departments of Nephrology Link\u00f6ping University Hospital Link\u00f6ping Sweden"},{"name":"Department of Medicine and Health Sciences Link\u00f6ping University Hospital Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Nayeri","sequence":"additional","affiliation":[{"name":"PEAS Institute Link\u00f6ping Sweden"},{"name":"Division of Infectious diseases Link\u00f6ping University Hospital Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Brudin","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences Link\u00f6ping University Hospital Link\u00f6ping Sweden"},{"name":"Department of Physiology Kalmar County Hospital Kalmar Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Sahlgren's University Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hahn\u2010Zoric","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Sahlgren's University Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,22]]},"reference":[{"issue":"3","key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/089686080102103S27","article-title":"Malnutrition, inflammation and atherosclerosis in peritoneal dialysis patients","volume":"21","author":"Stenvinkel P","year":"2001","journal-title":"Perit Dial Int"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.61.s80.18.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00119.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.09.007"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00463-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930701622783"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.05.023"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rinim.2011.12.002"},{"key":"e_1_2_6_10_1","article-title":"High concentrations of hepatocyte growth factor but low biological activity in patients with periodontitis","author":"L\u00f6nn J","year":"2013","journal-title":"J Periodontol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4236\/abb.2012.324068"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp784"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI46122"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr591"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00230112"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr596"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2012.04.004"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.08.008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2010.01000.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334424"},{"key":"e_1_2_6_21_1","unstructured":"ChitaliaN AfzaliB EdozieFet\u00a0al.Serum FGF\u201023 is linked with increased inflammatory cytokines in CKD stage 3\u20105. 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