{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:26:53Z","timestamp":1773296813046,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,10,27]],"date-time":"2013-10-27T00:00:00Z","timestamp":1382832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Function exhaustion of specific cytotoxic <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8+ T cell in chronic virus infection partly results from the low levels of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 help, but the mechanisms by which <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 help T cell required to control hepatitis B virus infection are not well understood. In this study, we investigated the role of interleukin\u201021\u2010producing <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ T cell response in viral control of hepatitis B virus infection. <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>cAg\u2010specific interleukin\u201021\u2010producing <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ T cells in blood were detected in patients with hepatitis B virus infection. Patients with acute hepatitis B had greater <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>cAg\u2010specific interleukin\u201021\u2010producing <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ T cells in blood compared with chronic hepatitis B patients, and there was no statistical significance between immune active chronic hepatitis B patients and inactive healthy carrier patients for these cells, whereas frequencies of these cells negatively correlated with <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content> levels but positively correlated with <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>c18\u201027\u2010specific <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3\u2010producing <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8+ T cells. Moreover, interleukin\u201021 sustained <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>c18\u201027\u2010specific <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8+ T cells <jats:italic>in vitro<\/jats:italic>, and interleukin\u201021 production by <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>cAg\u2010specific <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021\u2010producing <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ T cells of acute hepatitis B patients enhanced <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 and perforin expression by <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8+ T cells from chronic hepatitis B patients. Our results demonstrate that <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>cAg\u2010specific interleukin\u201021\u2010producing <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ T cell responses might contribute to viral control by sustaining <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8+ T cell antiviral function.<\/jats:p>","DOI":"10.1111\/sji.12099","type":"journal-article","created":{"date-parts":[[2013,8,20]],"date-time":"2013-08-20T09:54:43Z","timestamp":1376992483000},"page":"439-446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["<scp>HB<\/scp>cAg\u2010Specific <scp>IL<\/scp>\u201021\u2010Producing <scp>CD<\/scp>4+ T Cells are Associated with Relative Viral Control in Patients with Chronic Hepatitis B"],"prefix":"10.1111","volume":"78","author":[{"given":"L.","family":"Li","sequence":"first","affiliation":[{"name":"Department of Infectious 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