{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:13:48Z","timestamp":1770506028586,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T00:00:00Z","timestamp":1385596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tumour necrosis factor\u2010\u03b1\u2010induced protein\u20108 like\u20102 (<jats:styled-content style=\"fixed-case\">TIPE<\/jats:styled-content>2) is a newly identified immune negative regulator. The abnormal expression of <jats:styled-content style=\"fixed-case\">TIPE<\/jats:styled-content>2 has been found in several human inflammatory diseases. However, the expression level and clinical significance of <jats:styled-content style=\"fixed-case\">TIPE<\/jats:styled-content>2 in childhood asthma remain unclear. In this study, we detected <jats:styled-content style=\"fixed-case\">TIPE<\/jats:styled-content>2 expression in peripheral blood mononuclear cells (<jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content>) from 42 children with asthma and 39 healthy controls by <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> qRT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>estern blot. We also detected the levels of serum total immunoglobulin <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>), eosinophil (<jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content>), interleukin\u20104 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104) and interferon\u2010\u03b3 (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3) and analysed the correlations of <jats:styled-content style=\"fixed-case\">TIPE<\/jats:styled-content>2 expression with <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EO<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20104 and <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3. The results showed that <jats:styled-content style=\"fixed-case\">TIPE<\/jats:styled-content>2 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> and protein expression were decreased in children with asthma compared with healthy controls. The levels of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 in the children with asthma were obviously higher than those in normal controls, while the level of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 in patients with asthma was significantly lower than that in healthy subjects. Furthermore, the expression level of <jats:styled-content style=\"fixed-case\">TIPE<\/jats:styled-content>2 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> was negatively correlated with <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104. However, no statistically significant correlation was found between <jats:styled-content style=\"fixed-case\">TIPE<\/jats:styled-content>2 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression and serum <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 level. In conclusion, our data suggest that reduced <jats:styled-content style=\"fixed-case\">TIPE<\/jats:styled-content>2 expression may contribute to the pathogenesis of childhood asthma.<\/jats:p>","DOI":"10.1111\/sji.12110","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T22:05:05Z","timestamp":1381529105000},"page":"523-528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["The Expression and Significance of TIPE2 in Peripheral Blood Mononuclear Cells from Asthmatic Children"],"prefix":"10.1111","volume":"78","author":[{"given":"Y.","family":"Ma","sequence":"first","affiliation":[{"name":"Institute of Immunology Shandong University School of Medicine Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Immunology Shandong University School of Medicine Jinan Shandong China"},{"name":"Children's Medical Laboratory Diagnosis Center Qilu Children's Hospital of Shandong University Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Wei","sequence":"additional","affiliation":[{"name":"Shandong University School of Medicine Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Immunology Shandong University School of Medicine Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Wang","sequence":"additional","affiliation":[{"name":"Jinan Central Hospital affiliated to Shandong University Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Zhong","sequence":"additional","affiliation":[{"name":"Jinan Central Hospital affiliated to Shandong University Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Immunology Shandong University School of Medicine Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Immunology Shandong University School of Medicine Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Immunology Shandong University School of Medicine Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Immunology Shandong University School of Medicine Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Immunology Shandong University School of Medicine Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.04.017"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1522"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.4.2973"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.06.016"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103477"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.026"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2009.08.014"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2011.03.002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2010.08.003"},{"key":"e_1_2_7_11_1","first-page":"183","article-title":"Pathogenetic aspects of allergic respiratory syndromes","volume":"6","author":"Ricci M","year":"1991","journal-title":"Ann Ital Med Int"},{"key":"e_1_2_7_12_1","first-page":"14","article-title":"Immune response and pathophysiology of the allergic reaction","volume":"51","author":"Heusser CH","year":"1994","journal-title":"Ther Umsch"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(02)00235-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1992.tb00662.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1084"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2008.01464.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199201303260504"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1997.tb01169.x"},{"key":"e_1_2_7_19_1","first-page":"745","article-title":"Chinese Medical Association; 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