{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:30:43Z","timestamp":1790512243272,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T00:00:00Z","timestamp":1387411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"Abstract<\/jats:title>It has been previously shown that there are some interethnic differences in susceptibility to malaria between two sympatric ethnic groups of M<\/jats:styled-content>ali, the F<\/jats:styled-content>ulani and the D<\/jats:styled-content>ogon. The lower susceptibility to P<\/jats:styled-content>lasmodium falciparum<\/jats:italic> malaria seen in the F<\/jats:styled-content>ulani has not been fully explained by genetic polymorphisms previously known to be associated with malaria resistance, including haemoglobin S<\/jats:styled-content> (H<\/jats:styled-content>bS<\/jats:styled-content>), haemoglobin C<\/jats:styled-content> (H<\/jats:styled-content>bC<\/jats:styled-content>), alpha\u2010thalassaemia and glucose\u20106\u2010phosphate dehydrogenase (G<\/jats:styled-content>6PD<\/jats:styled-content>) deficiency. Given the observed differences in the distribution of F<\/jats:styled-content>c\u03b3RII<\/jats:styled-content>a allotypes among different ethnic groups and with malaria susceptibility that have been reported, we analysed the rs1801274\u2010R<\/jats:styled-content>131H<\/jats:styled-content> polymorphism in the F<\/jats:styled-content>c\u03b3RII<\/jats:styled-content>a gene in a study of D<\/jats:styled-content>ogon and F<\/jats:styled-content>ulani in M<\/jats:styled-content>ali (n<\/jats:italic>\u00a0=\u00a0939). We confirm that the F<\/jats:styled-content>ulani have less parasite densities, less parasite prevalence, more spleen enlargement and higher levels of total I<\/jats:styled-content>gG<\/jats:styled-content> antibodies (anti\u2010CSP<\/jats:styled-content>, anti\u2010AMA<\/jats:styled-content>1, anti\u2010MSP<\/jats:styled-content>1 and anti\u2010MSP<\/jats:styled-content>2) and more total I<\/jats:styled-content>gE<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.05) compared with the D<\/jats:styled-content>ogon ethnic group. Furthermore, the F<\/jats:styled-content>ulani exhibit higher frequencies of the blood group O<\/jats:styled-content> (56.5%) compared with the D<\/jats:styled-content>ogon (43.5%) (P<\/jats:italic>\u00a0<\u00a00.001). With regard to the F<\/jats:styled-content>c\u03b3RII<\/jats:styled-content>a polymorphism and allele frequency, the F<\/jats:styled-content>ulani group have a higher frequency of the H<\/jats:styled-content> allele (F<\/jats:styled-content>ulani 0.474, D<\/jats:styled-content>ogon 0.341, P<\/jats:italic>\u00a0<\u00a00.0001), which was associated with greater total I<\/jats:styled-content>gE<\/jats:styled-content> production (P<\/jats:italic>\u00a0=\u00a00.004). Our findings show that the F<\/jats:styled-content>c\u03b3RII<\/jats:styled-content>a polymorphism might have an implication in the relative protection seen in the F<\/jats:styled-content>ulani tribe, with confirmatory studies required in other malaria endemic settings.<\/jats:p>","DOI":"10.1111\/sji.12122","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:58:55Z","timestamp":1381543135000},"page":"43-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Fc gamma Receptor II<\/scp>a\u2010H<\/scp>131R<\/scp> Polymorphism and Malaria Susceptibility in Sympatric Ethnic Groups, Fulani and Dogon of M<\/scp>ali"],"prefix":"10.1111","volume":"79","author":[{"given":"B.","family":"Maiga","sequence":"first","affiliation":[{"name":"Malaria Research and Training Center\/Department of Epidemiology of Parasitic Diseases\/Faculty of Medicine Pharmacy and Odonto \u2013 Stomatology Bamako\/USTTB Mali"},{"name":"Department of Molecular Biosciences The Wenner\u2010Gren Institute Stockholm University Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dolo","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center\/Department of Epidemiology of Parasitic Diseases\/Faculty of Medicine Pharmacy and Odonto \u2013 Stomatology Bamako\/USTTB Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Tour\u00e9","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center\/Department of Epidemiology of Parasitic Diseases\/Faculty of Medicine Pharmacy and Odonto \u2013 Stomatology Bamako\/USTTB Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Dara","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center\/Department of Epidemiology of Parasitic Diseases\/Faculty of Medicine Pharmacy and Odonto \u2013 Stomatology Bamako\/USTTB Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tapily","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center\/Department of Epidemiology of Parasitic Diseases\/Faculty of Medicine Pharmacy and Odonto \u2013 Stomatology Bamako\/USTTB Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Campino","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute Hinxton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Sepulveda","sequence":"additional","affiliation":[{"name":"Faculty of Infectious and Tropical Diseases London School of Hygiene and Tropical Medicine London UK"},{"name":"Center of Statistics and Applications University of Lisbon Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Corran","sequence":"additional","affiliation":[{"name":"Faculty of Infectious and Tropical Diseases London School of Hygiene and Tropical Medicine London UK"},{"name":"National Institute for Biological Standards and Control Potters Bar, Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Rockett","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute Hinxton UK"},{"name":"Wellcome Trust Centre for Human Genetics University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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