{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:35:56Z","timestamp":1778661356094,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T00:00:00Z","timestamp":1387411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Berberine (<jats:styled-content style=\"fixed-case\">BBR<\/jats:styled-content>), an isoquinoline derivative alkaloid, has been extensively used in traditional Chinese medicine for the treatment of diarrhoea, rheumatic diseases, diabetes, etc. Recent studies have demonstrated new biological properties of <jats:styled-content style=\"fixed-case\">BBR<\/jats:styled-content> and suggested the possibility of <jats:styled-content style=\"fixed-case\">BBR<\/jats:styled-content> to be a therapeutic agent for some autoimmune diseases. To explore the effect of <jats:styled-content style=\"fixed-case\">BBR<\/jats:styled-content> on the development of experimental autoimmune neuritis (<jats:styled-content style=\"fixed-case\">EAN<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">BBR<\/jats:styled-content> was administered intragastrically daily to Lewis rats immunized with P0 peptide 180\u2013199 in Freund's complete adjuvant. We found <jats:styled-content style=\"fixed-case\">BBR<\/jats:styled-content> treatment resulted in amelioration of <jats:styled-content style=\"fixed-case\">EAN<\/jats:styled-content>, accompanied by suppressed lymphocyte (in particular <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cell) proliferation, downregulated Th1 (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) and Th2 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010) cytokines and reduced anti\u2010P0 peptide 180\u2013199 IgG1 and IgG2a. In brief, <jats:styled-content style=\"fixed-case\">BBR<\/jats:styled-content> played a role in ameliorating <jats:styled-content style=\"fixed-case\">EAN<\/jats:styled-content> by suppressing both cellular and humoral immunity. Thus, our study suggests that <jats:styled-content style=\"fixed-case\">BBR<\/jats:styled-content> may be a potential therapeutic agent for the autoimmune disease in the peripheral nervous system, such as Guillain\u2013Barr\u00e9 syndrome.<\/jats:p>","DOI":"10.1111\/sji.12123","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T01:37:41Z","timestamp":1387503461000},"page":"12-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Berberine Ameliorates Experimental Autoimmune Neuritis by Suppressing both Cellular and Humoral Immunity"],"prefix":"10.1111","volume":"79","author":[{"given":"H.","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology Shandong Provincial Qianfoshan Hospital Shandong University Jinan 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