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The <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> was obtained from 62 children suspected with meningitis. These patients were classified to the mumps meningitis (<jats:italic>n<\/jats:italic>\u00a0=\u00a019), echovirus 30 meningitis (<jats:italic>n<\/jats:italic>\u00a0=\u00a022) and non\u2010meningitis (<jats:italic>n<\/jats:italic>\u00a0=\u00a021) groups. The concentrations of interleukin\u20101 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101), interleukin\u20101 soluble receptor type 2 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>2), interleukin\u20108 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108), human interferon gamma (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03b3<\/jats:italic>) and human tumour necrosis factor alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>) were determined by immunoassay. A significant increase was noted in the levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic> and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>2 in the <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> of both meningitis groups as compared to controls. The concentrations of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03b3<\/jats:italic> and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101 differed significantly only between the mumps group and control. The levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03b3<\/jats:italic> and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic> were significantly higher in mumps meningitis when compared to the echovirus 30 group. Of all cytokines examined, only <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03b3<\/jats:italic> correlated with pleocytosis (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.58) in the mumps meningitis group. The increased <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> cytokine levels are markers of meningeal inflammation, and each virus may cause a specific profile of the cytokine pattern.<\/jats:p>","DOI":"10.1111\/sji.12131","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T09:02:44Z","timestamp":1386579764000},"page":"68-72","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Increased Levels of Cytokines in Cerebrospinal Fluid of Children with Aseptic Meningitis Caused by Mumps Virus and Echovirus 30"],"prefix":"10.1111","volume":"79","author":[{"given":"A.","family":"Sulik","sequence":"first","affiliation":[{"name":"Department of Pediatric Infectious Diseases Medical University of Bialystok Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kroten","sequence":"additional","affiliation":[{"name":"Department of 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