{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:20:07Z","timestamp":1787923207660,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T00:00:00Z","timestamp":1390435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neuromyelitis optica (<jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>) and multiple sclerosis (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) are two of the autoimmune inflammatory demyelinating diseases in the central nervous system. Complement is thought to have an important role in pathogenesis of these diseases, especially in <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>. However, the change of terminal complement complex (<jats:styled-content style=\"fixed-case\">TCC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> C<\/jats:styled-content>5b\u20109) in patients with <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content> is still unclear. Cerebrospinal fluid (<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>3a, <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>5a, s<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>5b\u20109 were measured by enzyme\u2010linked immunosorbent assay in patients with <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a026), <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a025) and other neurological disease (<jats:styled-content style=\"fixed-case\">OND<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a019). <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> levels of <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>5a in patients with <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content> were higher than patients with <jats:styled-content style=\"fixed-case\">OND<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.006). Increased <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> s<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>5b\u20109 were found in the patients with <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content> compared with patients with <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.029) and <jats:styled-content style=\"fixed-case\">OND<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0001). <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> s<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>5b\u20109 in patients with <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> were also higher than patients with <jats:styled-content style=\"fixed-case\">OND<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.030). Patients with <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content> revealed a trend to an increased disease disability with increased <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> s<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>5b\u20109 during relapse but not in <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>:<jats:italic> P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.006, MS: <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.097). <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> levels of s<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>5b\u20109 are increased in patients with <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content> and reflect the activation of complement in <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/sji.12132","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T09:02:43Z","timestamp":1386579763000},"page":"127-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Increased Soluble <scp>C<\/scp>5b\u20109 in <scp>CSF<\/scp> of Neuromyelitis Optica"],"prefix":"10.1111","volume":"79","author":[{"given":"H.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Anhui Medical University Hefei Anhui Province China"},{"name":"Department of Neurology Multiple Sclerosis Center The Third Affiliated Hospital of Sun\u2010yatsen University Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated 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