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The inhibitory effect of halofuginone (HF<\/jats:styled-content>), an active component of extracts derived from the plant alkaloid febrifugine, on collagen synthesis has been shown in animal models of the fibrotic disease. The aim of this study was to clarify the in vivo<\/jats:italic> effect of HF<\/jats:styled-content> on T<\/jats:styled-content>h17 cells in concanavalin A<\/jats:styled-content>\u2010induced fibrosis rats. H<\/jats:styled-content>aematoxylin\u2013eosin (HE<\/jats:styled-content>) staining and Masson staining were performed to observe collagen deposition. The presence of INF<\/jats:styled-content>\u2010gamma, TNF<\/jats:styled-content>\u2010alpha, IL<\/jats:styled-content>\u20106, IL<\/jats:styled-content>\u201017, IL<\/jats:styled-content>\u20101beta, IL<\/jats:styled-content>\u201033 and IL<\/jats:styled-content>\u201010 in serum and the presence of ROR<\/jats:styled-content>\u2010\u03b3<\/jats:italic>t, IL<\/jats:styled-content>\u201017, TGF<\/jats:styled-content>\u2010\u03b2<\/jats:italic>1 and \u03b1<\/jats:italic>\u2010SMA<\/jats:styled-content> in liver tissue were detected. Flow cytometry was performed to analyse the percentage of Th17 cells. We observed significantly lower levels of INF<\/jats:styled-content>\u2010gamma, TNF<\/jats:styled-content>\u2010alpha, IL<\/jats:styled-content>\u20106, IL<\/jats:styled-content>\u201017, IL<\/jats:styled-content>\u20101beta, TGF<\/jats:styled-content>\u2010\u03b2<\/jats:italic>1 and \u03b1<\/jats:italic>\u2010SMA<\/jats:styled-content> in HF<\/jats:styled-content>\u2010treated group of rats, and the percentage of Th17 cells in splenic lymphocyte was decreased well. Histological examination demonstrated that HF<\/jats:styled-content> significantly reduced the severity of liver fibrosis in HF<\/jats:styled-content>\u2010treated rats. We concluded that HF<\/jats:styled-content> (10\u00a0mg\/kg) exerts an antifibrotic impact on Th17 cells and its relative cytokines in rats with ConA\u2010induced fibrosis.<\/jats:p>","DOI":"10.1111\/sji.12144","type":"journal-article","created":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T18:32:41Z","timestamp":1388687561000},"page":"163-172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Effect of Antifibrotic Drug Halofugine on Th17 Cells in Concanavalin A\u2010Induced Liver Fibrosis"],"prefix":"10.1111","volume":"79","author":[{"given":"J.","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Immunology Medical College of Qingdao University QingDao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Immunology Medical College of Qingdao University QingDao 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