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Oral <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>almonella<\/jats:italic> Typhi Ty21a typhoid vaccine elicits a significant cross\u2010reactive immune response against <jats:italic>S<\/jats:italic>. Paratyphi A and B, and some reports suggest cross\u2010protective efficacy against the disease. These findings are ascribed to the O\u201012 antigen shared between the strains. The Vi capsular polysaccharide vaccine has been shown to elicit antibodies reactive with O\u20109,12. Twenty\u2010five volunteers immunized with the parenteral Vi vaccine (Typherix<jats:sup>\u00ae<\/jats:sup>) were explored for plasmablasts cross\u2010reactive with paratyphoid strains; the responses were compared to those in 25 age\u2010 and gender\u2010matched volunteers immunized with Ty21a (Vivotif<jats:sup>\u00ae<\/jats:sup>). Before vaccination, 48\/50 vaccinees had no plasmablasts reactive with the antigens. Seven days after vaccination, 15\/25 and 22\/25 Vi\u2010 and Ty21a\u2010vaccinated volunteers had circulating plasmablasts producing antibodies cross\u2010reactive with <jats:italic>S<\/jats:italic>. Paratyphi A, 18\/25 and 23\/25 with <jats:italic>S<\/jats:italic>. Paratyphi B and 16\/25 and 9\/25 with Paratyphi C, respectively. Compared to the Ty21a group, the Vi group showed significantly lower responses to <jats:italic>S<\/jats:italic>. Paratyphi A and B and higher to <jats:italic>S<\/jats:italic>. Paratyphi C. To conclude, the Vi vaccine elicited a cross\u2010reactive plasmablast response to <jats:italic>S<\/jats:italic>. Paratyphi C (Vi antigen in common) and less marked responses to <jats:italic>S<\/jats:italic>. Paratyphi A and B than the Ty21a preparation. <jats:italic>S<\/jats:italic>. Paratyphi A and B both being Vi\u2010negative, the result can be explained by trace amounts of bacterial cell wall O\u201012 antigen in the Vi preparation, despite purification. The clinical significance of this finding remains to be determined.<\/jats:p>","DOI":"10.1111\/sji.12151","type":"journal-article","created":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T18:35:05Z","timestamp":1388687705000},"page":"222-229","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cross\u2010Reactive Immune Response Induced by the Vi Capsular Polysaccharide Typhoid Vaccine Against <i>Salmonella<\/i> Paratyphi Strains"],"prefix":"10.1111","volume":"79","author":[{"given":"S. H.","family":"Pakkanen","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Helsinki University Central Hospital Helsinki Finland"},{"name":"Department of Bacteriology and Immunology Haartman Institute University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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