{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T01:37:29Z","timestamp":1772501849063,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T00:00:00Z","timestamp":1397952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) and atherosclerotic and aortic aneurysmal vascular diseases (<jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content>) are inflammatory conditions that share a number of predisposing factors. They have a complex genetic heritability and may share genetic risk factors, but a well\u2010defined relationship is still not determined. In addition, distinct genetic patterns of predisposition have been associated with these diseases. Here, we investigated the association of polymorphisms in the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101 gene locus with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> in a case\u2013case study analysing <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content> patients with or without <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>. Seventy\u2010four patients with <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content> of whom 36 had <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> were genotyped for single nucleotide polymorphisms in the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1A \u2010889 (rs1800587), <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1B +3954 (rs1143634) and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1B at \u2212511 (rs16944) genes and for <jats:styled-content style=\"fixed-case\">VNTR<\/jats:styled-content> polymorphisms in the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">RN<\/jats:styled-content> gene. A significantly higher frequency (17%) for allele 1 (four repeats) of the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">RN VNTR<\/jats:styled-content> gene was found among the <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> compared to those without <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>. In addition, the frequency of the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">RN VNTR<\/jats:styled-content> genotypes 1\/1 (4\/4 repeats) and 2\/2 (2\/2 repeats) were significantly higher and lower, respectively, in <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>. These findings suggest an association of genetic polymorphisms in the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1\u2010gene locus with risk for <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content>. The carriage of the risk genotypes, the development and the subsequent influence of <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> on systemic health may constitute an additional burden in the pathogenesis of <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content>. This emphasizes the importance of effective periodontal treatment in patients with <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/sji.12166","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T06:06:53Z","timestamp":1394518013000},"page":"338-345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Polymorphisms in the Interleukin\u20101 Gene Locus and Chronic Periodontitis in Patients with Atherosclerotic and Aortic Aneurysmal Vascular Diseases"],"prefix":"10.1111","volume":"79","author":[{"given":"Z.","family":"Armingohar","sequence":"first","affiliation":[{"name":"Department of Oral Biology Faculty of Dentistry University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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