{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T03:08:44Z","timestamp":1768878524068,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T00:00:00Z","timestamp":1403222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In humans, there are three members of type <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> interferon family, designated as <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03bb1 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201029), <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03bb2 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201028<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03bb<\/jats:italic>3 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201028B). Bacterial infections, including <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ycobacterium tuberculosis<\/jats:italic> infection, trigger the expression of interferon I and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> genes, but little is known about their effect on <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03bb<\/jats:italic> genes. It has been found that <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>.\u00a0tuberculosis<\/jats:italic> infection in A549 lung epithelial cells stimulate upregulation of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03bb<\/jats:italic>2 genes <jats:italic>in vitro<\/jats:italic>. The aim of this study was to determine the <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03bb<\/jats:italic>2 levels in sputum of patients with active pulmonary tuberculosis comparing with levels in healthy persons sputum and sputum of persons with latent tuberculosis. <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03bb<\/jats:italic>2 level in the samples was quantified with sandwich enzyme\u2010linked immunoassay kit for quantization of human <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03bb<\/jats:italic>2 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201028A). The <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03bb<\/jats:italic>2 level in sputum of patients with pulmonary tuberculosis was significantly higher comparing with <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03bb<\/jats:italic>2 levels in healthy group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) and latent tuberculosis group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005). Logistic regression analysis has shown that <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03bb<\/jats:italic>2 level in sputum is related to culture result (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a04.14; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.28\u201317.5; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.019). There was the correlation between Bartlett score and <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03bb<\/jats:italic>2 levels in group with pulmonary tuberculosis (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.641; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). In conclusion, we have found that the inflammatory cells in sputum can be source of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03bb<\/jats:italic> after receptor stimulation by <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>.\u00a0tuberculosis<\/jats:italic> components.<\/jats:p>","DOI":"10.1111\/sji.12178","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T09:09:05Z","timestamp":1396256945000},"page":"43-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Interferon Lambda\u20102 Levels in Sputum of Patients with Pulmonary <i>Mycobacterium tuberculosis<\/i> Infection"],"prefix":"10.1111","volume":"80","author":[{"given":"M.","family":"Travar","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology Faculty of Medicine Banja Luka University Banja Luka Republic of Srpska, Bosnia and Herzegovina"},{"name":"Department of Microbiology Clinic Centre Banja Luka Banja Luka Republic of Srpska, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Vucic","sequence":"additional","affiliation":[{"name":"Clinic for Pulmonary Diseases Clinic Centre Banja Luka Banja Luka Republic of Srpska, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Petkovic","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Faculty of Medicine Banja Luka University Banja Luka Republic of Srpska, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,20]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization.Global Tuberculosis Report 2013. 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