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However, the exact mechanism leading to the development of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> remains incomplete. There is a large body of evidence pointing towards the important role of toll\u2010like receptor (<jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>) activation and vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> deficiency in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> pathogenesis. In this article, we review the available data on the influence of <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>s' level of activation and vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> status on the risk of the development of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> in humans and rodent models. We also summarize the current information regarding the interactions between <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>s' level of activation, vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> status and various environmental factors, such as enteroviral infections, the gut microbiota and breastfeeding substitution, among others. Our results stipulate that vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> seems to protect against <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> by reducing the <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>s' level of activation.<\/jats:p>","DOI":"10.1111\/sji.12188","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T06:26:44Z","timestamp":1400653604000},"page":"75-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Role of Toll\u2010Like Receptors and Vitamin D in Diabetes Mellitus Type 1 \u2013 A Review"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8570-1812","authenticated-orcid":false,"given":"D. 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