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Suppressor of cytokine signalling (SOCS) proteins which negatively regulate the JAK\u2013STAT signalling pathway of cytokine induction may be dysregulated in BD. The expression of SOCS1 and 3 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> and protein was studied in peripheral blood mononuclear cells (PBMCs) and neutrophils of patients with BD and compared with healthy controls (HCs) and patients with recurrent aphthous stomatitis (RAS) using RT\u2010PCR, Western blot and immunohistochemistry. SOCS1 and 3 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> was also measured in buccal mucosal cells (BMC) of patients with BD and HCs. SOCS1 and 3 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> was significantly upregulated in PBMCs of patients with BD compared with HCs (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0149; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0007). In addition, there were subtle differences between expression in active and symptom\u2010free BD (quiescent BD). SOCS1 and SOCS 3 were also significantly upregulated in BMC from oral ulcers of BD compared with HCs (both at <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001). A differential expression of both SOCS1 and 3 was observed between PBMCs and neutrophils in patients with BD. Immunohistochemical analysis revealed differential expression of SOCS proteins in the buccal mucosa with an increased expression at the ulcer surface of ulcers than in the non\u2010ulcerated tissue. These observations suggest a dysregulation of the expression of these important regulators not only between patients with BD and healthy controls but also between mucosal and systemic tissues, which may reflect the nature of the aetiopathology of the disease.<\/jats:p>","DOI":"10.1111\/sji.12211","type":"journal-article","created":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T12:45:01Z","timestamp":1410353101000},"page":"369-376","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Differential Expression of Suppressor of Cytokine Signalling Proteins in Beh\u00e7et's Disease"],"prefix":"10.1111","volume":"80","author":[{"given":"M.","family":"Hamedi","sequence":"first","affiliation":[{"name":"Centre Clinical and Diagnostic Oral Sciences Institute of dentistry Bart's and The London School of Medicine and Dentistry London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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