{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T16:14:47Z","timestamp":1788020087521,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Beh\u00e7et's disease (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) is a chronic inflammatory autoimmune disease. Although raised levels of proinflammatory cytokines in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> have been reported, the pathogenesis is still unknown. The aim of this study was to investigate the association of <jats:italic><jats:styled-content style=\"fixed-case\">NFKB<\/jats:styled-content>1<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">NFKBIA<\/jats:styled-content><\/jats:italic> polymorphisms and their single and combined analysis effects on susceptibility of <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>urkish population. We analysed the distribution of <jats:italic><jats:styled-content style=\"fixed-case\">NFKB<\/jats:styled-content>1<\/jats:italic> \u201094 ins\/del <jats:styled-content style=\"fixed-case\">ATTG<\/jats:styled-content> (rs28362491) and <jats:italic><jats:styled-content style=\"fixed-case\">NFKBIA<\/jats:styled-content><\/jats:italic> 3\u2032 <jats:styled-content style=\"fixed-case\">UTR<\/jats:styled-content> A\u2192G (rs696) polymorphisms using <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RFLP<\/jats:styled-content> method in 89 patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> and 190 controls in this population. Statistical analysis of the results was performed by calculating <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, and 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> via <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> test and using <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>onferroni correction. According to the significant results of both single and combined genotype analysis, the frequencies of ins\/ins genotype and ins allele of rs28362491 were significantly higher in patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> (<jats:italic>P<\/jats:italic>c\u00a0=\u00a00.003, 0.004, respectively). Also, higher frequencies of the rs696 variant containing <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> genotype was found in patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> (<jats:italic>P<\/jats:italic>c\u00a0=\u00a00.0033), whereas no statistical significant differences in distribution of the alleles of rs696 polymorphism in patients and controls. In addition, according to the combined genotype analysis, the wild type of both rs28362491 and rs696 polymorphisms (ins\/ins\/<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> genotype) was also significantly higher in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> cases (<jats:italic>P<\/jats:italic>c\u00a0=\u00a00.044). Our findings prove that both single and combined genotype analysis of rs28362491 and rs696 polymorphisms indicate that the wild genotypes of both two <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s (ins\/ins and <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> genotypes) and ins\/ins\/<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> combined genotype are strongly associated with enhanced risk of <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> in a <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>urkish population.<\/jats:p>","DOI":"10.1111\/sji.12251","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T15:50:10Z","timestamp":1415029810000},"page":"81-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Association of <i><scp>NFKB<\/scp>1 and <scp>NFKBIA<\/scp><\/i> Polymorphisms in Relation to Susceptibility of <scp>B<\/scp>eh\u00e7et's Disease"],"prefix":"10.1111","volume":"81","author":[{"given":"G.","family":"Yenmis","sequence":"first","affiliation":[{"name":"Department of Medical Biology Cerrahpasa Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Oner","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Cerrahpasa Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cam","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Cerrahpasa Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Koc","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Cerrahpasa Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. 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