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Previous research on mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s has revealed a new paradigm of gene regulations and pathways involved in the pathogenesis of autoimmune disorders and malignant diseases. The roles of mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s in cellular processes, including cell differentiation, proliferation, apoptosis and immune functions, are not clearly understood. Mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s are easily detected in a variety of sources, including tissues, serum and other body fluids, and this make them a good biological sample for pathogenic studies and disease biomarker development. This review encompasses the current understanding of the roles of mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s in autoimmunity and the cellular and molecular mechanisms of mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s in various autoimmune diseases (<jats:styled-content style=\"fixed-case\">AIMD<\/jats:styled-content>s). Specifically, we focus on the target genes of mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s and the biological processes associated with autoimmune diseases with skin involvement, including systemic lupus erythematosus, psoriasis, systemic sclerosis, <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ehcet's disease and dermatomyositis. In addition, the diagnostic and therapeutic relevance of mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s that are involved in autoimmunity are elucidated to provide information for clinical implications.<\/jats:p>","DOI":"10.1111\/sji.12261","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T14:11:59Z","timestamp":1417183919000},"page":"153-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["The Role of Micro<scp>RNA<\/scp>s in Autoimmune Diseases with Skin Involvement"],"prefix":"10.1111","volume":"81","author":[{"given":"X.","family":"Deng","sequence":"first","affiliation":[{"name":"Hunan Key Laboratory of Medical Epigenetics Department of Dermatology Second Xiangya Hospital Central South University Changsha Hunan 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