{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:03:40Z","timestamp":1768464220665,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:00:00Z","timestamp":1424736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["075491\/Z\/04"],"award-info":[{"award-number":["075491\/Z\/04"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inherited variance in the <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012B<\/jats:italic> gene is associated with susceptibility to <jats:italic>Chlamydia trachomatis<\/jats:italic>\u2010induced tubal factor infertility and disease severity. In this study, our aim was to discover how polymorphisms in <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012\u2010coding genes influence <jats:italic>C.\u00a0trachomatis<\/jats:italic>\u2010induced immune responses and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012 production. The study population consisted of 240 women. <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012A<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012B<\/jats:italic> single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) were determined from isolated <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> using the Sequenom system with matrix\u2010assisted laser desorption\/ionization time\u2010of\u2010flight (<jats:styled-content style=\"fixed-case\">MALDI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>) mass spectrometry. We studied lymphocyte proliferative (<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>) responses to <jats:italic>C.\u00a0trachomatis<\/jats:italic> strains E and F elementary bodies (<jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content>s) and recombinant chlamydial heat\u2010shock protein 60 (<jats:styled-content style=\"fixed-case\">CHSP<\/jats:styled-content>60) antigen. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012p40 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012p70 levels were measured using the <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> Flex Set method. We found a statistically significant association between the <jats:italic>C.\u00a0trachomatis <\/jats:italic><jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content> antigen\u2010specific <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> response and the rs2853694 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). Our study demonstrates that the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012 cytokine family is involved in <jats:italic>C.\u00a0trachomatis<\/jats:italic>\u2010specific immune responses. Moreover, <jats:italic>C.\u00a0trachomatis<\/jats:italic>\u2010induced <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012 production and the <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012B<\/jats:italic> rs2853694 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> partially explain individual variation in the <jats:italic>C.\u00a0trachomatis <\/jats:italic><jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> response.<\/jats:p>","DOI":"10.1111\/sji.12264","type":"journal-article","created":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T12:15:28Z","timestamp":1420546528000},"page":"209-213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Contribution of <i><scp>IL<\/scp>\u201012A<\/i> and <i><scp>IL<\/scp>\u201012B<\/i> Polymorphisms to <i>Chlamydia trachomatis<\/i>\u2010Specific Cell\u2010Mediated Immune Responses"],"prefix":"10.1111","volume":"81","author":[{"given":"H.","family":"\u00d6hman","sequence":"first","affiliation":[{"name":"National Institute for Health and Welfare Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Natividad","sequence":"additional","affiliation":[{"name":"London School of Hygiene and Tropical Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bailey","sequence":"additional","affiliation":[{"name":"London School of Hygiene and Tropical Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ragoussis","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Human Genetics University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.\u2010L.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Human Genetics University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tiitinen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Halttunen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Paavonen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010M.","family":"Surcel","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2240-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000460"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(02)00291-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/652402"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1258\/095646202762226092"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197901183000305"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/428287"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2010.546365"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2009.00536.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2010.12.012"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/597620"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2392"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des136"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02946.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.5.1387"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.4049\/jimmunol.156.3.1207","article-title":"Regulation of bioactive IL\u201012 production in lipopolysaccharide\u2010stimulated human monocytes is determined by the expression of the p35 subunit","volume":"156","author":"Snijders A","year":"1996","journal-title":"J Immunol"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.436675"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.10.5518-5521.1999"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.10.6038-6040.2000"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2012-101214"},{"key":"e_1_2_6_23_1","first-page":"763","article-title":"Footprints of genetic susceptibility to pulmonary tuberculosis: cytokine gene variants in north Indians","volume":"135","author":"Abhimanyu","year":"2012","journal-title":"Indian J Med Res"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.2741\/2418"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.4049\/jimmunol.154.10.5071","article-title":"Dendritic cells produce IL\u201012 and direct the development of Th1 cells from naive CD4+ T cells","volume":"154","author":"Macatonia SE","year":"1995","journal-title":"J Immunol"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsji.12264","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.12264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T12:28:50Z","timestamp":1696163330000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sji.12264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,24]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/sji.12264"],"URL":"https:\/\/doi.org\/10.1111\/sji.12264","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,24]]},"assertion":[{"value":"2014-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}