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Spermidine is associated with regulation of cell growth, proliferation and differentiation, and with the suppression of oxidation and inflammation. Atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) is a chronic inflammatory skin disease that has a complex and multiple pathogenesis, which includes genetic abnormality, modified or abnormal immune response and the production of nitric oxide and reactive oxygen species. We investigated whether spermidine can relieve <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010like clinical manifestation induced by the continual application of 2,4\u2010dinitrofluorobenzene (<jats:styled-content style=\"fixed-case\">DNFB<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>\u2044Nga mice. Spermidine at concentrations of 1 or 10\u00a0mg\/kg reduced increasing ear swelling and attenuated oedema, haemorrhage and hyperkeratosis in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010like skin lesions. Repetitive application of <jats:styled-content style=\"fixed-case\">DNFB<\/jats:styled-content> induced inflammatory cell infiltration to skin lesions, whereas intraperitoneal injection of spermidine inhibited <jats:styled-content style=\"fixed-case\">DNFB<\/jats:styled-content>\u2010evoked infiltration of eosinophils, mast cells and T lymphocytes. Furthermore, spermidine suppressed mast cell degranulation and production of interferon\u2010gamma by activated <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cells in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010like skin lesions. Spermidine may be a potential therapeutic agent for treatment of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/sji.12274","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T13:24:47Z","timestamp":1422883487000},"page":"221-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Immune Response Against 2,4\u2010Dinitrofluorobenzene\u2010Induced Atopic Dermatitis\u2010Like Clinical Manifestation is Suppressed by Spermidine in <scp>NC<\/scp>\u2044Nga Mice"],"prefix":"10.1111","volume":"81","author":[{"given":"G.\u2010D.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Microbiology School of Medicine Kyung Hee University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.\u2010H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology School of Medicine Kyung Hee University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. 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