{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:20:53Z","timestamp":1778916053545,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T00:00:00Z","timestamp":1431475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"Abstract<\/jats:title>Although Th17 cells subsets improve immunity against extra and intracellular pathogens, and in modulating Th1 and other immune responses, its role on pregnancy\u2010associated malaria (PAM<\/jats:styled-content>) is unknown. This study aims to investigate the effects of PAM<\/jats:styled-content> on Th1 (IFN<\/jats:styled-content>\u2010\u03b3<\/jats:italic>, TNF<\/jats:styled-content>\u2010\u03b1<\/jats:italic>), IL<\/jats:styled-content>\u201010 family (IL<\/jats:styled-content>\u201010, IL<\/jats:styled-content>\u201019, IL<\/jats:styled-content>\u201022), Th17 (IL<\/jats:styled-content>\u201017A, IL<\/jats:styled-content>\u201023) cytokines and on CXCL<\/jats:styled-content>\u201010 chemokine profiles in pregnant women. Between 2010 and 2011, venous blood specimens from 107 volunteer pregnant Cameroonian women was used to determine parasitaemia microscopically and haemoglobin levels using HemoCue analyzer. Plasma levels of the biomarkers were determined by ELISA<\/jats:styled-content>. Parasitaemia was higher in women with low haemoglobin levels, parity and mother's age. IL<\/jats:styled-content>\u201010 and CXCL<\/jats:styled-content>\u201010 plasma levels were higher in the malaria infected and in anaemic women while IFN<\/jats:styled-content>\u2010\u03b3<\/jats:italic> and IL<\/jats:styled-content>\u201017A levels were higher in malaria non\u2010infected and in non\u2010anaemic women. Parasitaemia correlated positively with IL<\/jats:styled-content>\u201010 and CXCL<\/jats:styled-content>\u201010 levels but inversely with IFN<\/jats:styled-content>\u2010\u03b3<\/jats:italic> and IL<\/jats:styled-content>\u201017A. Haemoglobin levels were higher in women with low IL<\/jats:styled-content>\u201010 and CXCL<\/jats:styled-content>\u201010 levels, and in group with high IFN<\/jats:styled-content>\u2010\u03b3<\/jats:italic>, IL<\/jats:styled-content>\u201017A and IL<\/jats:styled-content>\u201023 levels. Only IL<\/jats:styled-content>\u201010 levels associated negatively with parity. Positive correlations were observed between Th17 (IL<\/jats:styled-content>\u201017A) and Th1 (IFN<\/jats:styled-content>\u2010\u03b3<\/jats:italic>, TNF<\/jats:styled-content>\u2010\u03b1<\/jats:italic>), IL<\/jats:styled-content>\u201010 family (IL<\/jats:styled-content>\u201019 and IL<\/jats:styled-content>\u201022) and Th17 (IL<\/jats:styled-content>\u201023) cytokines. Multivariate analysis showed association between: mother's age and IFN<\/jats:styled-content>\u2010\u03b3<\/jats:italic> levels, parasitaemia and IL<\/jats:styled-content>\u201010 and CXCL<\/jats:styled-content>\u201010 levels and haemoglobin levels, gestational age and IL<\/jats:styled-content>\u201017A levels. In conclusion, during PAM, CXCL<\/jats:styled-content>\u201010 and IL<\/jats:styled-content>\u201010 responses are implicated in the pathogenesis while Th17 and Th1 immune responses, via IL<\/jats:styled-content>\u201017A and IFN<\/jats:styled-content>\u2010\u03b3<\/jats:italic> might play protective roles.<\/jats:p>","DOI":"10.1111\/sji.12286","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T19:27:44Z","timestamp":1425324464000},"page":"508-514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of Pregnancy\u2010associated Malaria on T Cell Cytokines in Cameroonian Women"],"prefix":"10.1111","volume":"81","author":[{"given":"R.","family":"Megnekou","sequence":"first","affiliation":[{"name":"The Biotechnology Center University of Yaounde I Yaounde Cameroon"},{"name":"Department of Animal Biology and Physiology Faculty of Sciences University of Yaounde I Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lissom","sequence":"additional","affiliation":[{"name":"The Biotechnology Center University of Yaounde I Yaounde Cameroon"},{"name":"Department of Animal Biology and Physiology Faculty of Sciences University of Yaounde I Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Bigoga","sequence":"additional","affiliation":[{"name":"The Biotechnology Center University of Yaounde I Yaounde Cameroon"},{"name":"Department of Biochemistry Faculty of Science University of Yaounde I Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Djontu","sequence":"additional","affiliation":[{"name":"The Biotechnology Center University of Yaounde I Yaounde Cameroon"},{"name":"Department of Animal Biology and Physiology Faculty of Sciences University of Yaounde I Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5267.1502"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/378500"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01420-07"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.8.4288"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxp021"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003778"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-6-147"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048763"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/828256"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2014.10.007"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-387"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2012.02.071"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-15-16"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.06.002"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061308"},{"key":"e_1_2_9_17_1","first-page":"2379","article-title":"IL\u201017 and IL\u201022 are associated with protection against human kala azar caused by Leishmania donovani","volume":"119","author":"Pitta GR","year":"2009","journal-title":"J Clin Invest"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200535239"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsji.12286","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.12286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:34:05Z","timestamp":1695573245000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sji.12286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,13]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/sji.12286"],"URL":"https:\/\/doi.org\/10.1111\/sji.12286","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,13]]},"assertion":[{"value":"2014-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}