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Induction of an intracellular NO<\/jats:styled-content> pathway, triggered by the binding of IgE to CD<\/jats:styled-content>23 receptor in IFN<\/jats:styled-content>\u2010\u03b3<\/jats:italic>\/IL<\/jats:styled-content>\u20104 cytokines environment, was evaluated in localized cutaneous leishmaniasis (LCL<\/jats:styled-content>) carriers and positive Montenegro skin test (MST<\/jats:styled-content>) individuals without skin lesion (MT<\/jats:styled-content>+<\/jats:sup>SL<\/jats:styled-content>\u2212<\/jats:sup>). Our data demonstrated that the higher frequency of CD<\/jats:styled-content>23+<\/jats:sup>CD<\/jats:styled-content>14+<\/jats:sup> monocytes and the increased serum levels of IgE observed in the LCL<\/jats:styled-content> group were even higher in LCL<\/jats:styled-content> carriers with late lesions (LCL<\/jats:styled-content>\u226560). Furthermore, patients with LCL<\/jats:styled-content> presented increased NO<\/jats:styled-content> production after Leishmania (Viannia) braziliensis<\/jats:italic> stimulation and this NO<\/jats:styled-content> profile was independent of the time of the lesion (recent LCL<\/jats:styled-content><60 or late LCL<\/jats:styled-content>\u226560). We also showed that the increased frequency of IFN<\/jats:styled-content>\u2010\u03b3+<\/jats:sup> and IL<\/jats:styled-content>\u20104+<\/jats:sup>CD<\/jats:styled-content>4+<\/jats:sup> T cells is related to the MT<\/jats:styled-content>+<\/jats:sup>SL<\/jats:styled-content>\u2212<\/jats:sup> group. The results of biomarker signature curves demonstrated that in the MT<\/jats:styled-content>+<\/jats:sup>SL<\/jats:styled-content>\u2212<\/jats:sup> group, the index signature was characterized by DAF<\/jats:styled-content>\u20102T+<\/jats:sup>CD<\/jats:styled-content>14+<\/jats:sup>\/IL<\/jats:styled-content>\u20104+<\/jats:sup>CD<\/jats:styled-content>8+<\/jats:sup>\/IFN<\/jats:styled-content>\u2010\u03b3+<\/jats:sup>CD<\/jats:styled-content>4+<\/jats:sup>\/IL<\/jats:styled-content>\u20104+<\/jats:sup>CD<\/jats:styled-content>4+<\/jats:sup>. On the other hand, the LCL<\/jats:styled-content> group presented a higher index of DAF<\/jats:styled-content>\u20102T+<\/jats:sup>CD<\/jats:styled-content>14+<\/jats:sup>\/CD<\/jats:styled-content>23+<\/jats:sup>CD<\/jats:styled-content>14+<\/jats:sup>\/IL<\/jats:styled-content>\u20104+<\/jats:sup> CD<\/jats:styled-content>8+<\/jats:sup>, associated with a lower index of IFN<\/jats:styled-content>\u2010\u03b3+<\/jats:sup>CD<\/jats:styled-content>8+<\/jats:sup>. Considering the time of lesion, data analysis demonstrated that the main differences observed were highlighted in LCL<\/jats:styled-content><60 patients, with a higher index of CD<\/jats:styled-content>23+<\/jats:sup>CD<\/jats:styled-content>14+<\/jats:sup>, which was also present in LCL<\/jats:styled-content>\u226560 patients. In conclusion, our data suggest that the protective immune response involving CD<\/jats:styled-content>23\u2010IgE\u2010mediated NO<\/jats:styled-content> release is a hallmark of patients with LCL<\/jats:styled-content>. However, in MT<\/jats:styled-content>+<\/jats:sup>SL<\/jats:styled-content>\u2212<\/jats:sup> individuals, another different leishmanicidal mechanism seems to be involved.<\/jats:p>","DOI":"10.1111\/sji.12294","type":"journal-article","created":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T16:48:47Z","timestamp":1426870127000},"page":"515-524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Protective Profile Involving CD<\/scp>23\/IgE\u2010mediated NO<\/scp> Release is a Hallmark of Cutaneous Leishmaniasis Patients from the Xakriab\u00e1 Indigenous Community in Minas Gerais, Brazil"],"prefix":"10.1111","volume":"81","author":[{"given":"R.","family":"Carvalho\u2010Gontijo","sequence":"first","affiliation":[{"name":"Laboratory of Biomarkers for Diagnosis and Monitoring Ren\u00e9 Rachou Research Center FIOCRUZ Belo Horizonte MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Peruhype\u2010Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Laboratory of Biomarkers for Diagnosis and Monitoring Ren\u00e9 Rachou Research Center FIOCRUZ Belo Horizonte MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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