{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:55:00Z","timestamp":1790805300259,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T00:00:00Z","timestamp":1434585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008368","name":"Gigtforeningen","doi-asserted-by":"publisher","award":["R114-A2671"],"award-info":[{"award-number":["R114-A2671"]}],"id":[{"id":"10.13039\/100008368","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Galectin\u20103 has been suggested as a pro\u2010inflammatory mediator in rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>). Previous studies have reported overexpression of Galectin\u20103 in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> synovitis and increased levels in synovial fluid and serum in long\u2010standing <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> compared with osteoarthritis and healthy controls. Our objectives were to study whether serum Galectin\u20103 (1) exhibits circadian variation and\/or (2) responds to exercise in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> and controls. The study on circadian patterns (1) comprised eleven patients with newly diagnosed <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>, disease duration less than 6\u00a0months (<jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content>), 10 patients with long\u2010standing <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> [5\u201315\u00a0years (<jats:styled-content style=\"fixed-case\">LRA<\/jats:styled-content>)] and 16 self\u2010reportedly healthy control subjects. During 24\u00a0h, 7 blood samples were drawn at 3\u2010h intervals starting at 10\u00a0a.m. through 10\u00a0p.m. and at 7 and 10\u00a0a.m. on the following day. The study on the effect of physical activity (2) included 10 patients with <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content>, 10 with <jats:styled-content style=\"fixed-case\">LRA<\/jats:styled-content> and 14 controls. The participants underwent a standardized exercise programme and four blood samples were drawn before, during and after exercise. Serum Galectin\u20103 was quantified by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> (R&amp;D systems). (1) Galectin\u20103 was increased at baseline in both <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> subsets (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.08). There were no diurnal oscillations (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.85). Day\u2010to\u2010day variation amounted to 3%. (2) Baseline Galectin\u20103 was increased in <jats:styled-content style=\"fixed-case\">LRA<\/jats:styled-content> versus controls and <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01 and 0.05). Physical exercise induced 10\u201315% Galectin\u20103 increments in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> and controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) peaking after 1\u20133\u00a0h. To conclude, Galectin\u20103 did not exhibit circadian variation. Day\u2010to\u2010day variation was 3%. Exercise elicited comparable increments in patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> of short and long duration and controls, approaching normal after 1\u20133\u00a0h.<\/jats:p>","DOI":"10.1111\/sji.12301","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T06:13:59Z","timestamp":1428646439000},"page":"70-75","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Within\u2010day variation and influence of physical exercise on circulating Galectin\u20103 in patients with rheumatoid arthritis and healthy individuals"],"prefix":"10.1111","volume":"82","author":[{"given":"S. F.","family":"Issa","sequence":"first","affiliation":[{"name":"Department of Rheumatology Odense University Hospital Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. F.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Vejle Hospital Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Lottenburger","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Vejle Hospital Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Junker","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, Dept. Cancer &amp; Inflammation University of Southern Denmark Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Lindegaard","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Odense University Hospital Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"H\u00f8rslev\u2010Petersen","sequence":"additional","affiliation":[{"name":"King Christian X Hospital for Rheumatic Diseases Graasten Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Junker","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Odense University Hospital Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)31891-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297908040032"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2005.12.020"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2006.11.036"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05131.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp097"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.000129"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.12.031"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090353"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-1462"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2940"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24574"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30118"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11287"},{"issue":"11","key":"e_1_2_7_16_1","first-page":"146","article-title":"Galectin\u20103 in the systemic circulation is increased in newly diagnosed rheumatoid arthritis and is associated with anti\u2010CCP and bone marrow edema","volume":"66","author":"Issa SF","year":"2014","journal-title":"Arthritis Rheum"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/13547500903302927"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.02.029"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.051292"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2013-0601"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487313492069"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.023135"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-6-37"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsji.12301","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.12301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T19:55:29Z","timestamp":1696190129000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sji.12301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,18]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/sji.12301"],"URL":"https:\/\/doi.org\/10.1111\/sji.12301","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,18]]},"assertion":[{"value":"2015-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}