{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:14:16Z","timestamp":1789528456743,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T00:00:00Z","timestamp":1435881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>1 <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> lymphocytes are natural <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\u2010producing cells primarily found in peritoneum and mucosal sites. They perform vital functions during the early defence against viral and bacterial infections. Murine <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>1 cells express <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201033 receptor complex on activation. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201033 is a new addition to the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101 family with a strong role in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h2 immunity. <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>1 cells have been recognized to exacerbate contact sensitivity by producing <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20105 in response to interleukin\u201033. However, the exact response of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201033\/<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>2 signalling in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>1 cells is not completely understood. In this study, we report that murine <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>1 cells respond directly to <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201033 in a <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>2\u2010dependent manner. This interaction instigates <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>1b cell proliferation in a time\u2010dependent manner <jats:italic>in\u00a0vivo<\/jats:italic>. Furthermore, it also mediates monocyte\/macrophage and granulocyte recruitment via <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>1 cell release of chemokines (<jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20101 alpha). It was noted that upon stimulation, <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>1b cells additionally release an angiogenic inducer vascular endothelial growth factor and granulocyte\u2013monocyte colony\u2010stimulating factor (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>). Our findings suggest that these <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201033\u2010mediated <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>1 cells might be able to play a vital role in the recruitment and growth of monocytes and granulocytes.<\/jats:p>","DOI":"10.1111\/sji.12312","type":"journal-article","created":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T07:25:42Z","timestamp":1432279542000},"page":"118-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Interleukin\u201033 Triggers <scp>B<\/scp>1 Cell Expansion and Its Release of Monocyte\/Macrophage Chemoattractants and Growth Factors"],"prefix":"10.1111","volume":"82","author":[{"given":"Ammad","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Haematology and Immunology Faculty of Medicine Umm Al Qura University Makkah Saudi 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