{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T02:01:36Z","timestamp":1787796096042,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korea University Grant"},{"name":"Korea Healthcare Technology R&D Project of the Ministry of Health & Welfare","award":["R1417262"],"award-info":[{"award-number":["R1417262"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Varicella\u2010zoster virus (<jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>) is an important viral pathogen that is responsible for causing varicella (chickenpox) and herpes zoster (shingles). <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> has been shown to suppress early anti\u2010viral innate immune responses, but the exact mechanisms are not yet well understood. Here we demonstrate that host control of <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> is impaired by the expression of suppressor of cytokine signaling (<jats:styled-content style=\"fixed-case\">SOCS<\/jats:styled-content>)3. We used three different cell types to characterize <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>\u2010induced anti\u2010viral and inflammatory responses. Infection of human fibroblasts (<jats:styled-content style=\"fixed-case\">MRC<\/jats:styled-content>\u20105) and human macrophages (<jats:styled-content style=\"fixed-case\">THP<\/jats:styled-content>\u20101) with <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> triggered upregulation of anti\u2010viral responsive gene expression (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> IFN<\/jats:styled-content>\u2010<jats:italic>\u03b2<\/jats:italic>) in the early phases of infection, followed by the waning of these <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>s in the late phases of infection. Conversely, <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> infection in keratinocytes (HaCaT) resulted in a persistent increase in type I <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content> gene expression. Interestingly, increase in <jats:styled-content style=\"fixed-case\">SOCS<\/jats:styled-content>1 and 3 expressions coincided with a reduction in phosphorylation of the signal transducer and activator of transcription protein 3 (<jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3) in <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>\u2010infected <jats:styled-content style=\"fixed-case\">MRC<\/jats:styled-content>\u20105 cells. Furthermore, <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> infection increased the production of pro\u2010inflammatory cytokines, including interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20106, \u20108, and <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03b3<\/jats:italic>\u2010inducible protein 10 (<jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\u201010). Knockdown of <jats:styled-content style=\"fixed-case\">SOCS<\/jats:styled-content>3 inhibited viral replication and enhanced secretion levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, whereas overexpression of <jats:styled-content style=\"fixed-case\">SOCS<\/jats:styled-content>3 did not affect viral replication efficiency and host response. In conclusion, our data suggest that <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> infection induces <jats:styled-content style=\"fixed-case\">SOCS<\/jats:styled-content>3 expression, resulting in modulation of type I <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content> signaling and viral replication.<\/jats:p>","DOI":"10.1111\/sji.12323","type":"journal-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T15:06:51Z","timestamp":1434121611000},"page":"337-344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Suppressor of Cytokine Signaling 3 Expression Induced by Varicella\u2010Zoster Virus Infection Results in the Modulation of Virus Replication"],"prefix":"10.1111","volume":"82","author":[{"given":"E.\u2010J.","family":"Choi","sequence":"first","affiliation":[{"name":"BK21 Plus Graduate Program Biomedical Sciences College of Medicine Korea University Seoul Korea"},{"name":"Asia\u2010Pacific Alliance for the Control of Influenza College of Medicine Korea University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbiology Chungbuk National University Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. S.","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences College of Medicine Korea University Seoul Korea"},{"name":"Department of Microbiology College of Medicine Korea University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3215"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05098-11"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016870"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01147-10"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2093"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.4.2034"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000196"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01857-10"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00508-06"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-06-0274"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.05.039"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2012.04305.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.210575"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890380406"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8197455"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.4161\/jkst.23820"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2314"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00325-07"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70312-3"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2010.84"},{"key":"e_1_2_6_22_1","first-page":"173","article-title":"VZV infection of keratinocytes: production of cell\u2010free infectious virions in\u00a0vivo","volume":"342","author":"Gershon MD","year":"2010","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2010.42"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03350.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.16.8411-8420.2004"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.04.028"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900570"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003256"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.20.12658-12666.2005"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsji.12323","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.12323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T18:17:10Z","timestamp":1696184230000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sji.12323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,10]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/sji.12323"],"URL":"https:\/\/doi.org\/10.1111\/sji.12323","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,10]]},"assertion":[{"value":"2015-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}