{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:45:01Z","timestamp":1787316301776,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Polish National Science Centre","doi-asserted-by":"publisher","award":["2011\/01\/B\/NZ5\/01358"],"award-info":[{"award-number":["2011\/01\/B\/NZ5\/01358"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"Abstract<\/jats:title>\n \n Interaction between\n TL<\/jats:styled-content>\n 1A and death receptor 3 (\n DR<\/jats:styled-content>\n 3) co\u2010stimulates T cells, induces production of several pro\u2010inflammatory cytokines and has been linked to pathogenesis of inflammatory bowel disease (\n IBD<\/jats:styled-content>\n ). This study aimed to establish a link between expression of\n TL<\/jats:styled-content>\n 1A and selected\n TL<\/jats:styled-content>\n 1A\u2010induced pro\u2010inflammatory cytokines involved in\n IBD<\/jats:styled-content>\n pathogenesis (\n IL<\/jats:styled-content>\n \u20104,\n IL<\/jats:styled-content>\n \u201013,\n IL<\/jats:styled-content>\n \u201017A and\n IFN<\/jats:styled-content>\n \u2010\n \u03b3<\/jats:italic>\n ) and to investigate a connection between serum concentration of\n TL<\/jats:styled-content>\n 1A in patients with\n IBD<\/jats:styled-content>\n and activation of peripheral blood T cells. Elevated levels of\n IL<\/jats:styled-content>\n \u20104 (2.91\u2010fold) and\n IL<\/jats:styled-content>\n \u201013 (4.05\u2010fold)\n mRNA<\/jats:styled-content>\n were detected in the inflamed colon mucosa of patients with ulcerative colitis (\n UC<\/jats:styled-content>\n ),\n IFN<\/jats:styled-content>\n \u2010\n \u03b3<\/jats:italic>\n mRNA<\/jats:styled-content>\n was upregulated (3.23\u2010fold) in the inflamed colon mucosa of patients with Crohn's disease (\n CD<\/jats:styled-content>\n ), whereas upregulation of\n IL<\/jats:styled-content>\n \u201017A and\n TL<\/jats:styled-content>\n 1A\n mRNA<\/jats:styled-content>\n was present in the inflamed colon mucosa of patients with both\n CD<\/jats:styled-content>\n and\n UC<\/jats:styled-content>\n (\n IL<\/jats:styled-content>\n \u201017A: 4.48\u2010fold and 2.74\u2010fold,\n TL<\/jats:styled-content>\n 1A: 3.19\u2010fold and 3.22\u2010fold, respectively) vs. control subjects. We did not detect any changes in\n DR<\/jats:styled-content>\n 3\n mRNA<\/jats:styled-content>\n expression in the investigated groups of patients.\n TL<\/jats:styled-content>\n 1A\n mRNA<\/jats:styled-content>\n level in colon mucosa of patients with\n IBD<\/jats:styled-content>\n correlated only with the level of\n IL<\/jats:styled-content>\n \u201017A\n mRNA<\/jats:styled-content>\n but no other investigated cytokines. In colon mucosa, expression of\n TL<\/jats:styled-content>\n 1A and\n DR<\/jats:styled-content>\n 3 was localized to enterocytes and lamina propria mononuclear cells. We did not find any correlation between serum concentrations of\n TL<\/jats:styled-content>\n 1A and\n IL<\/jats:styled-content>\n \u201017A or changes of\n CD<\/jats:styled-content>\n 4(+) or\n CD<\/jats:styled-content>\n 8(+) lymphocytes phenotype in patients with\n IBD<\/jats:styled-content>\n . Therefore, our data indicate that\n TL<\/jats:styled-content>\n 1A may contribute to pathogenesis of\n IBD<\/jats:styled-content>\n via local but not systemic induction of\n IL<\/jats:styled-content>\n \u201017A but not\n IL<\/jats:styled-content>\n \u20104,\n IL<\/jats:styled-content>\n \u201013 or IFN\u2010\n \u03b3<\/jats:italic>\n .\n <\/jats:p>","DOI":"10.1111\/sji.12324","type":"journal-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T11:07:02Z","timestamp":1434107222000},"page":"352-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["TL<\/scp>\n 1A as a Potential Local Inducer of\n IL<\/scp>\n 17A Expression in Colon Mucosa of Inflammatory Bowel Disease Patients"],"prefix":"10.1111","volume":"82","author":[{"given":"T. J.","family":"\u015alebioda","sequence":"first","affiliation":[{"name":"Department of Histology Medical University of Gda\u0144sk Gda\u0144sk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bojarska\u2010Junak","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Medical University of Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Stanis\u0142awowski","sequence":"additional","affiliation":[{"name":"Department of Histology Medical University of Gda\u0144sk Gda\u0144sk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cyman","sequence":"additional","affiliation":[{"name":"Department of Histology Medical University of Gda\u0144sk Gda\u0144sk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M.","family":"Wierzbicki","sequence":"additional","affiliation":[{"name":"Department of Histology Medical University of Gda\u0144sk Gda\u0144sk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Roli\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Medical University of Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Celi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology with Endoscopic Unit Medical University of Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Kmie\u0107","sequence":"additional","affiliation":[{"name":"Department of Histology Medical University of Gda\u0144sk Gda\u0144sk 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