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In addition to genetic factors, a contribution of infection to disease induction has been proposed. In the pathogenesis of lupus, immune complexes of <jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content>s with nuclear antigens can form and both deposit in the tissue and stimulate cytokine production to intensify inflammation. As such, the extracellular release of nuclear antigens to form pathogenic immune complexes is an important step in the pathway to disease. This release has been considered the consequence of cell death, with apoptotic cells the relevant source of nuclear material. While apoptosis could serve this role, other death forms may act similarly. Among these death forms, pyroptosis, which can be induced by inflammasome activation during infection, has features suggesting involvement in lupus. Thus, unlike apoptosis, pyroptosis is a pro\u2010inflammatory process. Furthermore, pyroptosis leads to the release of intracellular contents including <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>, both of which can act as <jats:styled-content style=\"fixed-case\">DAMP<\/jats:styled-content>s (death\u00a0associated molecular patterns) to stimulate further inflammation. Importantly, pyroptosis can lead to the release of intact nuclei, suggesting a relationship to events in the formation of <jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content> cells. While the role of pyroptosis in <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> is hypothetical at this time, further analysis of this death form should provide new insights into lupus pathogenesis and provide the missing link between infection and the initiation of lupus by products of dead and dying cells.<\/jats:p>","DOI":"10.1111\/sji.12335","type":"journal-article","created":{"date-parts":[[2015,6,27]],"date-time":"2015-06-27T17:01:09Z","timestamp":1435424469000},"page":"218-224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["The Role of Cell Death in the Pathogenesis of <scp>SLE<\/scp>: Is Pyroptosis the Missing Link?"],"prefix":"10.1111","volume":"82","author":[{"given":"M.","family":"Magna","sequence":"first","affiliation":[{"name":"Division of Rheumatology and Immunology Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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