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Vaccination for filariasis by targeting different stages of the parasite will be a boon to the existing <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content> efforts of <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> which required repeated administration of the drug to reduce the infection level and sustained transmission. Onset of a filaria\u2010specific immune response achieved through antigen vaccines can act synergistically with these drugs to enhance the parasite killing. Multi\u2010epitope vaccine approach has been proved to be successful against several parasitic diseases as it overcomes the limitations associated with the whole antigen vaccines. Earlier results from our group suggested the protective efficacy of multi\u2010epitope vaccine comprising two immunodominant epitopes from <jats:italic>Brugia malayi<\/jats:italic> antioxidant thioredoxin (<jats:styled-content style=\"fixed-case\">TRX<\/jats:styled-content>), several epitopes from transglutaminase (<jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content>) and abundant larval transcript\u20102 (<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>\u20102). In this study, the prophylactic efficacy of the filarial epitope protein (<jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content>), a chimera of selective epitopes identified from our earlier study, was tested in a murine model (jird) of filariasis with L3 larvae. <jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content> conferred a significantly (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001) high protection (69.5%) over the control in jirds. We also observed that the multi\u2010epitope recombinant construct (<jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content>) induces multiple types of protective immune responses, thus ensuring the successful elimination of the parasite; this poses <jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content> as a potential vaccine candidate.<\/jats:p>","DOI":"10.1111\/sji.12340","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T15:03:14Z","timestamp":1436886194000},"page":"380-389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Chimeric Epitope Vaccine from Multistage Antigens for Lymphatic Filariasis"],"prefix":"10.1111","volume":"82","author":[{"given":"G.","family":"Anugraha","sequence":"first","affiliation":[{"name":"Centre for Biotechnology Anna University Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Madhumathi","sequence":"additional","affiliation":[{"name":"Centre for Biotechnology Anna University Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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